Specifications
- Antibody Type:Primary
- Antigen Name:CD209 molecule
- Antigen Symbol:CD209
- Clonality:Polyclonal
- Conjugation:Unconjugated
- ELISA:Yes
- Host:Rabbit
- ImmunoChemistry:Yes
- ImmunoFluorescence:Yes
- Reactivity:Human
- Western Blot:Yes
- Size:100 µg
- Epitope:Center
- Format:IgG
- Form:Liquid (sterile filtered)
- Gene ID:30835
- Antigen Synonyms:SIGN-R1|CD209 antigen-like protein A|dendritic cell-specific ICAM-3-grabbing non-integrin|CIRE|SIGNR5|Dcsign|DC-SIGN|DC-SIGN1|CDSIGN
- Concentration:1 mg/mL by UV absorbance at 280 nm
- Shipping Temperature:Dry Ice
- Immunogen:Anti-DC-SIGN antibody was prepared from whole rabbit serum produced by repeated immunizations with a synthetic peptide corresponding to amino acids near the internal region of human DC-DIGN.
- Purification:Anti-DC-SIGN Antibody was affinity purified from monospecific antiserum by immunoaffinity chromatography. Cross reactivity with DC-SIGN from other sources has not been determined.
- Cat. No.:10801-106
- Supplier no.:600-401-AT8
Specifications
About this item
Dendritic cells (DCs) that control immune responses were recently found to capture and transport HIV from the mucosal area to remote lymph nodes, where DCs hand over HIV to CD4+ T lymphocytes. DCs also amplify the amount of virus and extend the duration of viral infectivity. Multiple strains of HIV-1, HIV-2 and SIV bind to DCs via DC-SIGN. ICAM-3 is the natural ligand for DC-SIGN. A DC-SIGN homologue (termed DC-SIGNR, L-SIGN, and DC-SIGN2) was identified recently. DC-SIGN forms a novel gene family with DC-SIGNR and many alternatively spliced isoforms of DC-SIGN and DC-SIGNR. The expression of DC-SIGN was found in mucosal tissues including placenta, small intestine, and rectum.
Recommended Dilutions: ELISA: 1:10,000-1:20,000; Immunohistochemsitry: 10 ?g/mL; Immunofluorescence Microscopy: 20 ?g/mL; Western Blot: 1-2 ?g/mL; contains 0.02% (w/v) Sodium Azide
Type: Primary
Antigen: CD209
Clonality: Polyclonal
Clone:
Conjugation: Unconjugated
Epitope: Center
Host: Rabbit
Isotype: IgG1
Reactivity: Human