- Antibody Type:Primary
- Antigen Name:Tumor Necrosis Factor Receptor Superfamily Member 10C
- Antigen Symbol:TNFRSF10C
- Clonality:Polyclonal
- Conjugation:Unconjugated
- ELISA:Yes
- Host:Rabbit
- ImmunoFluorescence:Yes
- Reactivity:Human,Rat,Mouse
- Western Blot:Yes
- Size:100 µg
- Epitope:Extracellular
- Format:IgG
- Form:Liquid (sterile filtered)
- Gene ID:8794
- Antigen Synonyms:DCR1|TRID|TRAIL-R3|TRAILR3|DCR1-TNFR|CD263|LIT
- Concentration:1 mg/mL by UV absorbance at 280 nm
- Shipping Temperature:Dry Ice
- Immunogen:Anti-DcR1 antibody was prepared from whole rabbit serum produced by repeated immunizations with a peptide corresponding to amino acids in the extracellular domain of human DcR1 precursor.
- Purification:Anti-DcR1 Antibody was affinity purified from monospecific antiserum by immunoaffinity chromatography. Cross reactivity with DcR1 from other sources has not been determined.
- Cat. No.:10801-098
- Supplier no.:600-401-AT6
Apoptosis is induced by certain cytokines including TNF and Fas ligand in the TNF family through their death domain containing receptors. TRAIL/Apo2L is a new member of the TNF family and induces apoptosis of a variety of tumor cell lines. DR4 and DR5 are the recently identified functional receptors for TRAIL. Two decoy receptors for TRAIL have been identified and designated DcR1/TRID/TRAIL-R3/LIT and DcR2/TRAIL-R4/TRUNDD. DcR1 has extracellular TRAIL-binding domain but lacks intracellular signaling domain. It is a glycophospholipid-anchored cell surface protein. DcR1 transcripts are expressed in many normal human tissues but not in most cancer cell lines. Overexpression of DcR1 did not induce apoptosis, but attenuated TRAIL-induced apoptosis.
Recommended Dilutions: ELISA: 1:10,000; Immunofluorescence Microscopy: 10 ?g/mL; Western Blot: 1 ?g/mL; contains 0.02% (w/v) Sodium Azide
Type: Primary
Antigen: TNFRSF10C
Clonality: Polyclonal
Clone:
Conjugation: Unconjugated
Epitope: Extracellular
Host: Rabbit
Isotype:
Reactivity: Human, Mouse, Rat