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- Antibody Type:Primary
- Antigen Name:Atypical Chemokine Receptor 1 (Duffy blood group)
- Antigen Symbol:ACKR1
- Clonality:Polyclonal
- Conjugation:Unconjugated
- ELISA:Yes
- Host:Rabbit
- ImmunoChemistry:Yes
- Isotype:
- Reactivity:Human,Rat,Mouse
- Western Blot:Yes
- Size:100 µg
- Environmentally Preferable:
- Epitope:C-Terminal
- Format:IgG
- Form:Liquid (sterile filtered)
- Gene ID:2532
- Antigen Synonyms:CCBP1|CD234|GpFy|DARC|GPD|WBCQ1|FY|Dfy
- Concentration:1 mg/mL by UV absorbance at 280 nm
- Shipping Temperature:Dry Ice
- Immunogen:Anti-DARC antibody was prepared from whole rabbit serum produced by repeated immunizations with a 16 amino acid synthetic peptide from near the C-terminus of human DARC.
- Purification:Anti-DARC Antibody was affinity purified from monospecific antiserum by immunoaffinity chromatography. Cross reactivity with DARC from other sources has not been determined.
- Cat. No.:10800-980
- Supplier no.:600-401-AS6
DARC, also known as the Duffy antigen/chemokine receptor, is a seven-transmembrane protein homologous to the classical chemokine G-protein coupled receptors (GPCRs) with the exception of the motif required for G protein coupling. DARC can bind with high affinity several chemokines without transducing any signal, suggesting it may modulate the signals normally induced by these chemokines. Recently, DARC was found to interact with KAI1, a four transmembrane protein recently identified as a tumor metastasis suppressor protein. It is thought that tumor cells dislodged from the primary tumor and expressing KAI1 interact with DARC proteins expressed on vascular cells, transmitting a senescent signal to the tumor cells, while tumor cells that have lost KAI1 expression can proliferate and potentially give rise to metastases. At least three isoforms of DARC are known to exist.
Recommended Dilutions: ELISA: 1:5000-1:20,000; Immunohistochemsitry: 2.5 ?g/mL; Western Blot: 0.5-2 ?g/mL; contains 0.02% (w/v) Sodium Azide
Type: Primary
Antigen: ACKR1
Clonality: Polyclonal
Clone:
Conjugation: Unconjugated
Epitope: C-Terminal
Host: Rabbit
Isotype:
Reactivity: Human, Mouse, Rat