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Specifications
- Antibody Type:Primary
- Antigen Name:Prostaglandin D2 Receptor 2
- Antigen Symbol:PTGDR2
- Clonality:Polyclonal
- Conjugation:Unconjugated
- ELISA:Yes
- Host:Rabbit
- ImmunoChemistry:Yes
- ImmunoFluorescence:Yes
- Isotype:
- Reactivity:Human,Rat,Mouse
- Western Blot:Yes
- Size:100 µg
- Environmentally Preferable:
- Epitope:N-Terminal
- Format:IgG
- Form:Liquid (sterile filtered)
- Gene ID:11251
- Antigen Synonyms:GPR44|CD294|CRTH2|DL1R|DP2|prostaglandin D2 receptor 2
- Concentration:1 mg/mL by UV absorbance at 280 nm
- Shipping Temperature:Dry Ice
- Immunogen:Anti-CRTH2 antibody was prepared from whole rabbit serum produced by repeated immunizations with a 18 amino acid synthetic peptide from near the N-terminus of human CRTH2.
- Purification:Anti-CRTH2 Antibody was affinity purified from monospecific antiserum by immunoaffinity chromatography. Cross reactivity with CRTH2 from other sources has not been determined.
- Cat. No.:10800-924
- Supplier no.:600-401-AP0
Specifications
About this item
The chemoattractant receptor-homologous molecule expressed on Th2 cells (CRTH2) is a recently identified receptor for the prostaglandin D2 (PGD2) in addition to the classic prostaglandin D receptor. CRTH2 is expressed on Th2 cells and eosinophils and mediates chemotaxis of these cells to PGD2 and is thus thought to be a key receptor mediating eosinophil and Th2 recruitment during allergic responses. However, CRTH2-null mice showed enhanced eosinophil recruitment into the lung consistent with observations that the CRTH2-null mice produced significantly higher amounts of interleukin-5 (IL-5) and IL-3. This suggests that CRTH2 plays a nonredundant role in restricting eosinophilia and allergic response in vivo. At least two different isoforms of CRTH2 are known to exist.
Recommended Dilutions: ELISA: 1:10,000; Immunohistochemsitry: 2.5 µg/mL; Immunofluorescence Microscopy: 20 ?g/mL; Western Blot: 1 ?g/mL; contains 0.02% (w/v) Sodium Azide
Type: Primary
Antigen: PTGDR2
Clonality: Polyclonal
Clone:
Conjugation: Unconjugated
Epitope: N-Terminal
Host: Rabbit
Isotype:
Reactivity: Human, Mouse, Rat