Specifications
- Antibody Type:Primary
- Antigen Name:clusterin
- Antigen Symbol:CLU
- Clonality:Polyclonal
- Conjugation:Unconjugated
- ELISA:Yes
- Host:Rabbit
- ImmunoChemistry:Yes
- Reactivity:Human
- Western Blot:Yes
- Size:100 µg
- Format:IgG
- Form:Liquid (sterile filtered)
- Gene ID:1191
- Antigen Synonyms:SGP-2|NA1/NA2|KUB1|SP-40|TRPM-2|SGP2|CLU1|APOJ|CLI|APO-J|TRPM2|AAG4|CLU2
- Concentration:1 mg/mL by UV absorbance at 280 nm
- Shipping Temperature:Dry Ice
- Immunogen:Anti-Clusterin antibody was raised recombinant human Clusterin isoform 1.
- Purification:Anti-Clusterin Antibody was affinity purified from monospecific antiserum by immunoaffinity chromatography. Cross reactivity with Clusterin from other sources has not been determined.
- Cat. No.:10802-410
- Supplier no.:600-401-AM0
Specifications
About this item
Clusterin, also known as Apolipoprotein J (ApoJ), is a ubiquitous multifunctional glycoprotein that can interact with a broad spectrum of molecules such as complement components, various receptors, and the Alzheimer's b-amyloid peptide. Clusterin expression is increased in Alzheimer's disease brain tissue and clusterin-immunoreactive amyloid plaques are found associated with phospho-tau-positive dystrophic neurites and it has been suggested that clusterin facilitates the conversion of diffuse b-amyloid deposits into amyloid and enhances tau phosphorylation in neurites around these plaques. Other reports show that clusterin expression is decreased in proliferating cells and is upregulated in quiescent and senescent cells, suggesting that it may also play a role in aging and tumorigenesis suppression. Clusterin exists in at least two distinct isoforms.
Recommended Dilutions: ELISA: 1:5000-1:10000; Immunohistochemsitry: 10 µg/mL; Western Blot: 0.5-1 ?g/mL; contains 0.02% (w/v) Sodium Azide
Type: Primary
Antigen: CLU
Clonality: Polyclonal
Clone:
Conjugation: Unconjugated
Epitope:
Host: Rabbit
Isotype:
Reactivity: