Specifications
- Antibody Type:Primary
- Antigen Name:Caspase 8
- Antigen Symbol:CASP8
- Clonality:Polyclonal
- Conjugation:Unconjugated
- ELISA:Yes
- Host:Rabbit
- Reactivity:Human,Mouse
- Western Blot:Yes
- Size:100 µg
- Epitope:C-Terminal
- Format:IgG
- Form:Liquid (sterile filtered)
- Gene ID:841
- Antigen Synonyms:FLICE|caspase 8|MACH-beta-1/2/3/4 protein|FADD-homologous ICE/CED-3-like protease|MCH5|apoptotic protease Mch-5|FADD-like ICE|MACH-alpha-1/2/3 protein|CAP4|ALPS2B|apoptotic cysteine protease|Casp-8|MORT1-associated ced-3 homolog|caspase-8|apoptosis-related cysteine protease|ICE-like apoptotic protease 5|MACH
- Concentration:1 mg/mL by UV absorbance at 280 nm
- Shipping Temperature:Dry Ice
- Immunogen:Anti-Caspase-8 antibody was prepared from whole rabbit serum produced by repeated immunizations with a 15 amino acid synthetic peptide from near the C-terminus human caspase-8 isoform E.
- Purification:Anti-Caspase-8 Antibody was affinity purified from monospecific antiserum by immunoaffinity chromatography. Cross reactivity with Caspase-8 from other sources has not been determined.
- Cat. No.:10800-562
- Supplier no.:600-401-AE2
Specifications
About this item
Caspases are a family of cysteine proteases that can be divided into the apoptotic and inflammatory caspase subfamilies. Unlike the apoptotic caspases, members of the inflammatory subfamily are generally not involved in cell death but are associated with the immune response to microbial pathogens. The apoptotic subfamily can be further divided into initiator caspases, which are activated in response to death signals, and executioner caspases, which are activated by the initiator caspases and are responsible for cleavage of cellular substrates that ultimately lead to cell death. Caspase-8 is an initiator caspase that was identified as a member of the Fas/APO-1 death-inducing signaling complex. The adaptor molecule FADD couples procaspase-8 to the Fas receptor death domain; subsequent oligomerization promotes procaspase-8 autoactivation. FLIP, a catalytically inactive caspase-8-like molecule inhibits these interactions and thus can inhibit apoptosis. This antibody will only detect isoform E of caspase-8.
Recommended Dilutions: ELISA: 1:10,000; Western Blot: 1 ?g/mL; contains 0.02% (w/v) Sodium Azide
Type: Primary
Antigen: CASP8
Clonality: Polyclonal
Clone:
Conjugation: Unconjugated
Epitope: C-Terminal
Host: Rabbit
Isotype: IgG1
Reactivity: Human, Mouse