- Antibody Type:Primary
- Antigen Name:Caspase 4
- Antigen Symbol:CASP4
- Clonality:Polyclonal
- Conjugation:Unconjugated
- ELISA:Yes
- Host:Rabbit
- ImmunoChemistry:Yes
- ImmunoFluorescence:Yes
- Reactivity:Human
- Western Blot:Yes
- Size:100 µg
- Epitope:Center
- Format:IgG
- Form:Liquid (sterile filtered)
- Gene ID:837
- Antigen Synonyms:ICE(rel)III|ICH-3|caspase 5|caspase-5|CASP-4|Mih1/TX|CASP-5|caspase 4|protease ICH-2|ICEREL-III|ICE(rel)-III|caspase-4|protease TY|protease ICH-3|ICE(rel)II|TY protease|TX|ICE(rel)-II|ICH-2|apoptosis-related cysteine protease|apoptotic cysteine protease Mih1/TX|ICEREL-II|protease TX
- Concentration:1 mg/mL by UV absorbance at 280 nm
- Shipping Temperature:Dry Ice
- Immunogen:Anti-Caspase-4 antibody was prepared from whole rabbit serum produced by repeated immunizations with a 15 amino acid synthetic peptide from near the internal region of human Caspase-4.
- Purification:Anti-Caspase-4 Antibody was affinity purified from monospecific antiserum by immunoaffinity chromatography. Depending on cell lines or tissues used, other cleavage products may be observed.
- Cat. No.:10802-080
- Supplier no.:600-401-AD4
Caspases are a family of cysteine proteases that can be divided into the apoptotic and inflammatory caspase subfamilies. Unlike the apoptotic caspases, members of the inflammatory subfamily are generally not involved in cell death but are associated with the immune response to microbial pathogens. Members of this subfamily include caspase-1, -4, -5, and -12. Activation of these caspases results in the cleavage and activation of proinflammatory cytokines such as IL-1b and IL-18. Caspase-4 was initially identified as a homologous protein to Caspase-1 and the C. elegans Ced-3 which could induce apoptosis in transfected cells. More recent studies have shown that it can be activated by ER stress and has been suggested to be involved in multiple neuronal pathologies such as Alzheimer's disease.
Recommended Dilutions: ELISA: 1:10,000-1:20,000; Immunohistochemsitry: 2 µg/mL; Immunofluorescence Microscopy: 10 ?g/mL; Western Blot: 1-2 ?g/mL; contains 0.02% (w/v) Sodium Azide
Type: Primary
Antigen: CASP4
Clonality: Polyclonal
Clone:
Conjugation: Unconjugated
Epitope: Center
Host: Rabbit
Isotype: IgG1
Reactivity: Human