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Specifications
- Antibody Type:Primary
- Antigen Name:Calpain 6
- Antigen Symbol:CAPN6
- Clonality:Polyclonal
- Conjugation:Unconjugated
- ELISA:Yes
- Host:Rabbit
- ImmunoChemistry:Yes
- ImmunoFluorescence:Yes
- Isotype:
- Reactivity:Human,Rat,Mouse
- Western Blot:Yes
- Size:100 µg
- Environmentally Preferable:
- Epitope:C-Terminal
- Format:IgG
- Form:Liquid (sterile filtered)
- Gene ID:827
- Antigen Synonyms:CANPX|CAPNX|DJ914P14.1|CalpM
- Concentration:1 mg/mL by UV absorbance at 280 nm
- Shipping Temperature:Dry Ice
- Immunogen:Anti-CAPN6 antibody was prepared from whole rabbit serum produced by repeated immunizations with a 18 amino acid synthetic peptide from near the C-terminus of human CAPN6.
- Purification:Anti-CAPN6 Antibody was affinity purified from monospecific antiserum by immunoaffinity chromatography. Cross reactivity with CAPN6 from other sources has not been determined.
- Cat. No.:10799-914
- Supplier no.:600-401-AA8
Specifications
About this item
Calpains make up a ubiquitously expressed, well-conserved family of calcium-dependent cysteine proteases. The calpain proteins are heterodimers consisting of an invariant small subunit and variable large subunits. This large subunit possesses a cysteine protease domain, and both subunits possess calcium-binding domains. Calpains have been implicated in neurodegenerative processes as their activation can be triggered by calcium influx and oxidative stress. Calpain 6 (CAPN6) is most similar to Calpain 5; the C-terminal region of CAPN6 lacks homology to the calmodulin-like domain of other vertebrate calpains. CAPN6 is thought to be involved in the regulation of microtubule dynamics and cytoskeletal organization. CAPN6 has also been recently identified as an HIV dependency factor (HDF), suggesting that CAPN6 may be an important drug target in HIV treatment.
Recommended Dilutions: ELISA: 1:5000-1:10000; Immunohistochemsitry: 2.5 ?g/mL; Immunofluorescence Microscopy: 20 ?g/mL; Western Blot: 0.5-1 ?g/mL; contains 0.02% (w/v) Sodium Azide
Type: Primary
Antigen: CAPN6
Clonality: Polyclonal
Clone:
Conjugation: Unconjugated
Epitope: C-Terminal
Host: Rabbit
Isotype: IgG1
Reactivity: Human, Mouse, Rat