Specifications
- Antibody Type:Primary
- Antigen Name:BCL2-Like 14
- Antigen Symbol:BCL2L14
- Clonality:Polyclonal
- Conjugation:Unconjugated
- ELISA:Yes
- Host:Rabbit
- ImmunoChemistry:Yes
- ImmunoFluorescence:Yes
- Reactivity:Human,Rat,Mouse
- Western Blot:Yes
- Size:100 µg
- Epitope:N-Terminal
- Format:IgG
- Form:Liquid (sterile filtered)
- Gene ID:79370
- Antigen Synonyms:Apoptosis facilitator Bcl-2-like protein 14|Apoptosis regulator Bcl-G|Bcl2-L-14|Bcl-G|BCLG
- Concentration:1 mg/mL by UV absorbance at 280 nm
- Shipping Temperature:Dry Ice
- Immunogen:Anti-Bcl-G antibody was prepared from whole rabbit serum produced by repeated immunizations with a peptide corresponding to 15 amino acids near the N-terminus of human Bcl-G.
- Purification:Anti-Bcl-G Antibody is purified by ion exchange chromatography. Although antibody should react with both isoforms, only the Bcl-GS protein has been observed
- Cat. No.:10802-040
- Supplier no.:200-401-Z48
Specifications
About this item
Members in the Bcl-2 family are critical regulators of apoptosis by either inhibiting or promoting cell death. Bcl-2 homology 3 (BH3) domain is a potent death domain. BH3 domain containing pro-apoptotic proteins, including Bad, Bax, Bid, Bik, and Hrk, form a growing subclass of the Bcl-2 family. A novel BH3 domain containing protein was recently identified and designated Bcl-G. The mRNA of Bcl-G encodes 2 isoforms, Bcl-GL, which is widely expressed in multiple tissues, and Bcl-GS, which is only found in testis. The Bcl-GS protein is predominantly localized to cytoplasmic organelles whereas Bcl-GL was distributed throughout the cytosol. Overexpression of either protein induced apoptosis, although Bcl-GS was far more potent than Bcl-GS. Apoptosis induction was dependent on the BH3 domain and could be suppressed by co-expression with the anti-apoptotic Bcl-XL protein.
Recommended Dilutions: ELISA: 1:25,000-1:100,000; Immunohistochemsitry: 2 µg/mL; Immunofluorescence Microscopy: 10 µg/mL; Western Blot: 2.5 - 5 ?g/mL; contains 0.02% (w/v) Sodium Azide
Type: Primary
Antigen: BCL2L14
Clonality: Polyclonal
Clone:
Conjugation: Unconjugated
Epitope: N-Terminal
Host: Rabbit
Isotype:
Reactivity: Human, Mouse, Rat