Specifications
- Antibody Type:Primary
- Antigen Name:Anthrax Toxin Receptor 1
- Antigen Symbol:ANTXR1
- Clonality:Polyclonal
- Conjugation:Unconjugated
- ELISA:Yes
- Host:Rabbit
- ImmunoChemistry:Yes
- ImmunoFluorescence:Yes
- Reactivity:Human,Rat,Mouse
- Western Blot:Yes
- Size:100 µg
- Epitope:Center
- Format:IgG
- Form:Liquid (sterile filtered)
- Gene ID:84168
- Antigen Synonyms:ATR|Anthrax toxin receptor 1 [Precursor]|Tumor endothelial marker 8|TEM8|ANTXR1
- Concentration:1 mg/mL by UV absorbance at 280 nm
- Shipping Temperature:Dry Ice
- Immunogen:Anti-ATR antibody was prepared from whole rabbit serum produced by repeated immunizations with a peptide corresponding to 13 amino acids near the internal region of human ATR.
- Purification:Anti-ATR Antibody is purified by ion exchange chromatography. Will recognize all three isoforms.
- Cat. No.:10800-238
- Supplier no.:200-401-Y96
Specifications
About this item
The Anthrax toxin receptor (ATR) was initially discovered as the tumor endothelial marker 8 (TEM8). This protein, which exists in three isoforms (36, 40, and 60 kDa), is highly expressed in tumor vessels as well as in the vasculature of developing embryos, suggesting that it may normally play a role in angiogenesis. However, it also acts as the receptor for anthrax toxin. Following the binding of this protein by the protective antigen (PA) of anthrax, PA is cleaved and heptamerizes to form the binding site for both edema factor (EF) and lethal factor (LF). This complex is then endocytosed by the cell; acidification in endosomes allows the release of EF and LF into the cytoplasm where they interfere with MAPK signaling and induce apoptosis.
Recommended Dilutions: ELISA: 1:5000-1:20,000; Immunohistochemsitry: 2 ?g/mL; Immunofluorescence Microscopy: 10 ?g/mL; Western Blot: 0.5 - 2 µg/mL; contains 0.02% (w/v) Sodium Azide
Type: Primary
Antigen: ANTXR1
Clonality: Polyclonal
Clone:
Conjugation: Unconjugated
Epitope: Center
Host: Rabbit
Isotype:
Reactivity: Human, Mouse, Rat