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Anti-ATF4 Mouse Monoclonal Antibody (RPE (R-Phycoerythrin)) [clone: S360A-24]
Anti-ATF4 Mouse Monoclonal Antibody (RPE (R-Phycoerythrin)) [clone: S360A-24]
  10800-178
Anti-ATF4 Mouse Monoclonal Antibody (RPE (R-Phycoerythrin)) [clone: S360A-24]
  10800-178
 :  200-308-W61
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  • Antibody Type:
    Primary
  • Antigen Name:
    Activating Transcription Factor 4
  • Antigen Symbol:
    ATF4
  • Clonality:
    Monoclonal
  • Clone:
    S360A-24
  • Conjugation:
    RPE (R-Phycoerythrin)
  • ELISA:
    Yes
  • Host:
    Mouse
  • ImmunoChemistry:
    Yes
  • Isotype:
  • Reactivity:
    Human,
    Rat
  • Western Blot:
    Yes
  • Size:
    100 µg
  • Environmentally Preferable:
  • Epitope:
    C-Terminal
  • Format:
    IgG2a
  • Form:
    Liquid (sterile filtered)
  • Gene ID:
    468
  • Antigen Synonyms:
    DNA-binding protein TAXREB67|cAMP-dependent transcription factor ATF-4|Cyclic AMP-dependent transcription factor ATF-4|TXREB|TaxREB67|Tax-responsive enhancer element-binding protein 67|CREB2|Activating transcription factor 4|cAMP-responsive element-binding protein 2|CREB-2|Cyclic AMP-responsive element-binding protein 2|ATF4
  • Concentration:
    1mg/mL by UV absorbance at 280 nm
  • Shipping Temperature:
    Wet Ice
  • Immunogen:
    Anti-ATF4 Antibody was produced by repeated immunization of mice with a fusion protein containing amino acids 25-327 of human ATF4.
  • Purification:
    Anti-ATF4 Antibody was purified from concentrated tissue culture supernate by Protein G chromatography. BLAST analysis suggests that it is 85% identical to mouse, 86% identical to rat and <50% identical to ATF5. Will not cross react with ATF5.
  • Cat. No.:
    10800-178
  • Supplier no.:
    200-308-W61

 

 

Cyclic AMP-dependent transcription factor ATF-4 (ATF4) is a basic leucine-zipper (bZip) transcription factor, which regulates amino acid metabolism, DNA damage repair, chromatin remodeling, and apoptosis in response to cellular and ER stress. ATF4 works with various proteins, such as C/EBP homology protein (CHOP), aspargine synthetase (ASNS), and cAMP response element (CRE) among others to mediate cellular stress. ATF4 also regulates glucose homeostasis by suppressing beta-cell proliferation and insulin production. Furthermore, ATF4 targets the histone demethylase JMJD3 to alter chromatin structure and enhance gene transcription in response to amino acid deprivation. Anti-ATF4 is ideal for researchers interested in Cell Signaling, Oncology, Cell Differentiation, and Apoptosis; relevant pathways include MAPK signaling pathways, Activation of cAMP-Dependent PKA, CREB pathways, GPCR pathways and Rho Family GTPases.

Recommended Dilutions: ELISA: 1:10,000; Immunohistochemsitry: User Optimized; Western Blot: 1:1000; 0.1% (w/v) Sodium Azide

Type: Primary
Antigen: ATF4
Clonality: Monoclonal
Clone: S360A-24
Conjugation: RPE (R-Phycoerythrin)
Epitope: C-Terminal
Host: Mouse
Isotype:
Reactivity: Human, Rat