- Antibody Type:Primary
- Antigen Name:Activating Transcription Factor 4
- Antigen Symbol:ATF4
- Clonality:Monoclonal
- Clone:S360A-24
- Conjugation:RPE (R-Phycoerythrin)
- ELISA:Yes
- Host:Mouse
- ImmunoChemistry:Yes
- Reactivity:Human,Rat
- Western Blot:Yes
- Size:100 µg
- Epitope:C-Terminal
- Format:IgG2a
- Form:Liquid (sterile filtered)
- Gene ID:468
- Antigen Synonyms:DNA-binding protein TAXREB67|cAMP-dependent transcription factor ATF-4|Cyclic AMP-dependent transcription factor ATF-4|TXREB|TaxREB67|Tax-responsive enhancer element-binding protein 67|CREB2|Activating transcription factor 4|cAMP-responsive element-binding protein 2|CREB-2|Cyclic AMP-responsive element-binding protein 2|ATF4
- Concentration:1mg/mL by UV absorbance at 280 nm
- Shipping Temperature:Wet Ice
- Immunogen:Anti-ATF4 Antibody was produced by repeated immunization of mice with a fusion protein containing amino acids 25-327 of human ATF4.
- Purification:Anti-ATF4 Antibody was purified from concentrated tissue culture supernate by Protein G chromatography. BLAST analysis suggests that it is 85% identical to mouse, 86% identical to rat and <50% identical to ATF5. Will not cross react with ATF5.
- Cat. No.:10800-178
- Supplier no.:200-308-W61
Cyclic AMP-dependent transcription factor ATF-4 (ATF4) is a basic leucine-zipper (bZip) transcription factor, which regulates amino acid metabolism, DNA damage repair, chromatin remodeling, and apoptosis in response to cellular and ER stress. ATF4 works with various proteins, such as C/EBP homology protein (CHOP), aspargine synthetase (ASNS), and cAMP response element (CRE) among others to mediate cellular stress. ATF4 also regulates glucose homeostasis by suppressing beta-cell proliferation and insulin production. Furthermore, ATF4 targets the histone demethylase JMJD3 to alter chromatin structure and enhance gene transcription in response to amino acid deprivation. Anti-ATF4 is ideal for researchers interested in Cell Signaling, Oncology, Cell Differentiation, and Apoptosis; relevant pathways include MAPK signaling pathways, Activation of cAMP-Dependent PKA, CREB pathways, GPCR pathways and Rho Family GTPases.
Recommended Dilutions: ELISA: 1:10,000; Immunohistochemsitry: User Optimized; Western Blot: 1:1000; 0.1% (w/v) Sodium Azide
Type: Primary
Antigen: ATF4
Clonality: Monoclonal
Clone: S360A-24
Conjugation: RPE (R-Phycoerythrin)
Epitope: C-Terminal
Host: Mouse
Isotype:
Reactivity: Human, Rat