Specifications
- Antibody Type:Primary
- Antigen Name:CD209 molecule
- Antigen Symbol:CD209
- Clonality:Monoclonal
- Clone:8B6
- Conjugation:Unconjugated
- ELISA:Yes
- Host:Mouse
- ImmunoChemistry:Yes
- Reactivity:Human
- Western Blot:Yes
- Size:100 µg
- Epitope:Extracellular
- Form:Liquid (sterile filtered)
- Gene ID:30835
- Antigen Synonyms:SIGN-R1|CD209 antigen-like protein A|dendritic cell-specific ICAM-3-grabbing non-integrin|CIRE|SIGNR5|Dcsign|DC-SIGN|DC-SIGN1|CDSIGN
- Concentration:1 mg/mL by UV absorbance at 280 nm
- Shipping Temperature:Dry Ice
- Immunogen:Anti-DC-SIGN antibody was produced by repeated immunizations in mice with recombinant His-tagged protein fragment corresponding to the extracellular region of human DC-SIGN.
- Purification:Anti-DC-SIGN Monoclonal Antibody was Protein A purified from monospecific antiserum by immunoaffinity purification. Cross reactivity with DC-SIGN [8B6] from other sources has not been determined.
- Cat. No.:10801-104
- Supplier no.:200-301-AU0
Specifications
About this item
Dendritic cells (DCs) that control immune responses were recently found to capture and transport HIV from the mucosal area to remote lymph nodes, where DCs hand over HIV to CD4+ T lymphocytes. DCs also amplify the amount of virus and extend the duration of viral infectivity. Multiple strains of HIV-1, HIV-2 and SIV bind to DCs via DC-SIGN. ICAM-3 is the natural ligand for DC-SIGN. A DC-SIGN homologue (termed DC-SIGNR, L-SIGN, and DC-SIGN2) was identified recently. DC-SIGN forms a novel gene family with DC-SIGNR and many alternatively spliced isoforms of DC-SIGN and DC-SIGNR are known to exisit. The expression of DC-SIGN was found in mucosal tissues including placenta, small intestine, and rectum.
Recommended Dilutions: ELISA: 1:10,000-1:20,000; Immunohistochemsitry: 5-10 ?g/mL; Western Blot: 1-2 ?g/mL; contains 0.02% (w/v) Sodium Azide
Type: Primary
Antigen: CD209
Clonality: Monoclonal
Clone: 8B6
Conjugation: Unconjugated
Epitope: Extracellular
Host: Mouse
Isotype: IgG1
Reactivity: Human