Specifications
- Antibody Type:Primary
- Antigen Name:transmembrane emp24-like trafficking protein 10 (yeast)
- Antigen Symbol:TMED10
- Clonality:Polyclonal
- Conjugation:Unconjugated
- ELISA:Yes
- Host:Rabbit
- ImmunoChemistry:Yes
- ImmunoFluorescence:Yes
- Isotype:IgG
- Reactivity:Human,Rat,Mouse
- Western Blot:Yes
- Size:0.02 mg
- Cross Adsorption:No
- Form:Liquid
- Gene ID:P49755
- Antigen Synonyms:TMED10
- Storage Buffer:TMP21 Antibody is supplied in PBS containing 0.02% sodium azide.
- Storage Temperature:TMP21 antibody can be stored at 4 °C for three months and –20 °C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
- Concentration:1 mg/mL
- Shipping Temperature:4 °C
- Immunogen:TMP21 antibody was raised against a 19 amino acid synthetic peptide from near the carboxy terminus of human TMP21. The immunogen is located within amino acids 160 - 210 of TMP21.
- Purification:TMP21 Antibody is affinity chromatography purified via peptide column.
- Cat. No.:10749-810
- Supplier no.:3997_S
Specifications
About this item
TMP21 Antibody: TMP21 is a ubiquitously expressed protein that is involved in vesicular targeting and protein transport. More recent experiments have shown that it is also a component in the presenilin complex and modulates the gamma-secretase but not the epsilon-secretase cleavage activity of the amyloid precursor protein. The presenilin complex is composed of the proteins APH1, nicastrin, and PEN2 in addition to presenilin-1. Together, these proteins cleave the amyloid precursor protein at what is known as the gamma- and epsilon-sites and can lead to the accumulation of the Abeta cleavage product that is associated with Alzheimer's disease. Co-immunoprecipitation experiments using antibodies against these proteins also yielded TMP21 indicating that TMP21 may play a role in the regulation of this complex. Suppression of TMP21 expression by siRNA in transfected cells caused increased gamma-secretase activity but not epsilon-secretase activity, and increased Abeta production, demonstrating that TMP21 can modulate gamma-secretase activity.
Type: Primary
Antigen: TMED10
Clonality: Polyclonal
Clone:
Conjugation: Unconjugated
Epitope:
Host: Rabbit
Isotype: IgG
Reactivity: Human, Mouse, Rat