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Anti-BCL2L13 Rabbit Polyclonal Antibody
Anti-BCL2L13 Rabbit Polyclonal Antibody
Catalog # 10749-498
Supplier:  Prosci
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Anti-BCL2L13 Rabbit Polyclonal Antibody
Catalog # 10749-498
Supplier:  Prosci
Supplier Number:  3023_S

Specifications

  • Antibody Type:
    Primary
  • Antigen Name:
    BCL2-like 13 (apoptosis facilitator)
  • Antigen Symbol:
    BCL2L13
  • Clonality:
    Polyclonal
  • Conjugation:
    Unconjugated
  • ELISA:
    Yes
  • Host:
    Rabbit
  • ImmunoChemistry:
    Yes
  • ImmunoFluorescence:
    Yes
  • Isotype:
    IgG
  • Reactivity:
    Human,
    Rat,
    Mouse
  • Western Blot:
    Yes
  • Size:
    0.02 mg
  • Cross Adsorption:
    No
  • Form:
    Liquid
  • Gene ID:
    Q9BXK5
  • Antigen Synonyms:
    BCL2L13
  • Storage Buffer:
    Bcl-rambo Antibody is supplied in PBS containing 0.02% sodium azide.
  • Storage Temperature:
    Bcl-rambo antibody can be stored at 4 °C for three months and –20 °C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
  • Concentration:
    1 mg/mL
  • Shipping Temperature:
    4 °C
  • Immunogen:
    Bcl-rambo antibody was raised against a 15 amino acid synthetic peptide from near the center of human Bcl-rambo. The immunogen is located within amino acids 280 - 330 of Bcl-rambo.
  • Purification:
    Bcl-rambo Antibody is affinity chromatography purified via peptide column.
  • Cat. No.:
    10749-498
  • Supplier no.:
    3023_S

Specifications

About this item

Bcl-rambo Antibody: Apoptosis plays a major role in normal organism development, tissue homeostasis, and removal of damaged cells. Disruption of this process has been implicated in a variety of diseases such as cancer. Members of the Bcl-2 family are known to be critical regulators of this process. These proteins are characterized by the presence of several conserved motifs termed Bcl-2 homology (BH) domains. A novel, widely expressed member termed Bcl-rambo was recently identified. This protein is localized to mitochondria in mammalian cells and its overexpression induces apoptosis which could be blocked by co-expression of inhibitor of apoptosis proteins (IAPs) such as XIAP, cIAP1, and cIAP2. Bcl-rambo shows overall homology to the anti-apoptotic members containing BH motifs, but unlike Bcl-2, the C-terminal membrane anchor of Bcl-rambo is preceded by a unique 250 amino acid insertion. This region by itself can induce apoptosis more efficiently than the Bcl-2 homology regions, suggesting that Bcl-rambo may be important other pro-apoptotic pathways.

Type: Primary
Antigen: BCL2L13
Clonality: Polyclonal
Clone:
Conjugation: Unconjugated
Epitope:
Host: Rabbit
Isotype: IgG
Reactivity: Human, Mouse, Rat