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Anti-BACE2 Rabbit Polyclonal Antibody
Anti-BACE2 Rabbit Polyclonal Antibody
Catalog # 10749-368
Supplier:  Prosci
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Anti-BACE2 Rabbit Polyclonal Antibody
Catalog # 10749-368
Supplier:  Prosci
Supplier Number:  2249_S

Specifications

  • Antibody Type:
    Primary
  • Antigen Name:
    beta-site APP-cleaving enzyme 2
  • Antigen Symbol:
    BACE2
  • Clonality:
    Polyclonal
  • Conjugation:
    Unconjugated
  • ELISA:
    Yes
  • Host:
    Rabbit
  • ImmunoChemistry:
    Yes
  • Isotype:
    IgG
  • Reactivity:
    Human
  • Western Blot:
    Yes
  • Size:
    0.02 mg
  • Epitope:
    near the C-Terminus
  • Cross Adsorption:
    No
  • Form:
    Liquid
  • Gene ID:
    Q9Y5Z0
  • Antigen Synonyms:
    BACE2
  • Storage Buffer:
    BACE2 Antibody is supplied in PBS containing 0.02% sodium azide.
  • Molecular Weight:
    Predicted: 57 kDa Observed: 57 kDa
  • Storage Temperature:
    BACE2 antibody can be stored at 4 °C for three months and –20 °C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
  • Shipping Temperature:
    4 °C
  • Immunogen:
    BACE2 antibody was raised against a peptide corresponding to amino acids near the carboxy terminus of human BACE2. The immunogen is located within the last 50 amino acids of BACE2.
  • Purification:
    BACE2 Antibody is affinity chromatography purified via peptide column.
  • Cat. No.:
    10749-368
  • Supplier no.:
    2249_S

Specifications

About this item

BACE2 Antibody: Accumulation of the amyloid-beta (Abeta) plaque in the cerebral cortex is a critical event in the pathogenesis of Alzheimer's disease. Abeta peptide is generated by proteolytic cleavage of the beta-amyloid protein precursor (APP) at beta- and gamma-sites by proteases. The long-sought beta-secretase was recently identified by several groups independently and designated beta-site APP cleaving enzyme (BACE) and aspartyl protease 2 (Asp2). BACE/Asp2 is a novel transmembrane aspartic protease and co-localizes with APP. A BACE homolog was recently cloned and designated BACE2, Asp1, DRAP (for Down region aspartic protease), and memapsin 1. BACE2 also cleaves APP at b-site and at a different site within Abeta. BACE2 locates on chromosome 21q22.3, the so-called ‘Down critical region', suggesting that BACE2 and Abeta may also contribute to the pathogenesis of Down syndrome.

Type: Primary
Antigen: BACE2
Clonality: Polyclonal
Clone:
Conjugation: Unconjugated
Epitope:
Host: Rabbit
Isotype: IgG
Reactivity: Human