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Anti-BBC3 Mouse Monoclonal Antibody [clone: 2A8F6]
Anti-BBC3 Mouse Monoclonal Antibody [clone: 2A8F6]
Catalog # 10749-152
Supplier:  Prosci
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Anti-BBC3 Mouse Monoclonal Antibody [clone: 2A8F6]
Catalog # 10749-152
Supplier:  Prosci
Supplier Number:  PM-4523_S

Specifications

  • Antibody Type:
    Primary
  • Antigen Name:
    BCL2 binding component 3
  • Antigen Symbol:
    BBC3
  • Clonality:
    Monoclonal
  • Clone:
    2A8F6
  • Conjugation:
    Unconjugated
  • ELISA:
    Yes
  • Host:
    Mouse
  • Isotype:
    IgG1
  • Reactivity:
    Human,
    Rat
  • Western Blot:
    Yes
  • Size:
    0.02 mg
  • Cross Adsorption:
    No
  • Form:
    Liquid
  • Gene ID:
    Q9BXH1
  • Antigen Synonyms:
    BBC3
  • Storage Buffer:
    PUMA Monoclonal Antibody is supplied in PBS containing 0.02% sodium azide.
  • Storage Temperature:
    PUMA monoclonal antibody can be stored at –20 °C, stable for one year.
  • Concentration:
    1 mg/mL
  • Shipping Temperature:
    4 °C
  • Immunogen:
    Recombinant protein corresponding to amino acids 76 - 170 of human PUMA-alpha.
  • Purification:
    PUMA Monoclonal Antibody is immunoaffinity chromotography purified IgG.
  • Cat. No.:
    10749-152
  • Supplier no.:
    PM-4523_S

Specifications

About this item

PUMA Monoclonal Antibody: Apoptosis is related to many diseases and development. The p53 tumor-suppressor protein induces apoptosis through transcriptional activation of several genes. A novel p53 inducible pro-apoptotic gene was identified recently and designated PUMA (for p53 upregulated modulator of apoptosis) and bbc3 (for Bcl-2 binding component 3) in human and mouse. PUMA/bbc3 is one of the pro-apoptotic Bcl-2 family members including Bax and Noxa, which are also transcriptional targets of p53. The PUMA gene encodes two BH3 domain-containing proteins termed PUMAalpha and PUMAbeta ;. PUMA proteins bind Bcl-2, localize to the mitochondria, and induce cytochrome c release and apoptosis in response to p53. PUMA may be a direct mediator of p53-induced apoptosis.

Type: Primary
Antigen: BBC3
Clonality: Monoclonal
Clone: 2A8F6
Conjugation: Unconjugated
Epitope:
Host: Mouse
Isotype: IgG1
Reactivity: Human, Rat