Specifications
- Antibody Type:Primary
- Antigen Name:BCL2 binding component 3
- Antigen Symbol:BBC3
- Clonality:Monoclonal
- Clone:2A8F6
- Conjugation:Unconjugated
- ELISA:Yes
- Host:Mouse
- Isotype:IgG1
- Reactivity:Human,Rat
- Western Blot:Yes
- Size:0.02 mg
- Cross Adsorption:No
- Form:Liquid
- Gene ID:Q9BXH1
- Antigen Synonyms:BBC3
- Storage Buffer:PUMA Monoclonal Antibody is supplied in PBS containing 0.02% sodium azide.
- Storage Temperature:PUMA monoclonal antibody can be stored at –20 °C, stable for one year.
- Concentration:1 mg/mL
- Shipping Temperature:4 °C
- Immunogen:Recombinant protein corresponding to amino acids 76 - 170 of human PUMA-alpha.
- Purification:PUMA Monoclonal Antibody is immunoaffinity chromotography purified IgG.
- Cat. No.:10749-152
- Supplier no.:PM-4523_S
Specifications
About this item
PUMA Monoclonal Antibody: Apoptosis is related to many diseases and development. The p53 tumor-suppressor protein induces apoptosis through transcriptional activation of several genes. A novel p53 inducible pro-apoptotic gene was identified recently and designated PUMA (for p53 upregulated modulator of apoptosis) and bbc3 (for Bcl-2 binding component 3) in human and mouse. PUMA/bbc3 is one of the pro-apoptotic Bcl-2 family members including Bax and Noxa, which are also transcriptional targets of p53. The PUMA gene encodes two BH3 domain-containing proteins termed PUMAalpha and PUMAbeta ;. PUMA proteins bind Bcl-2, localize to the mitochondria, and induce cytochrome c release and apoptosis in response to p53. PUMA may be a direct mediator of p53-induced apoptosis.
Type: Primary
Antigen: BBC3
Clonality: Monoclonal
Clone: 2A8F6
Conjugation: Unconjugated
Epitope:
Host: Mouse
Isotype: IgG1
Reactivity: Human, Rat