To order chemicals, medical devices, or other restricted products please provide ID that includes your business name & shipping address via email [email protected] or fax 484.881.5997 referencing your VWR account number. Acceptable forms of ID are:
- • State issued document with your organization's Federal Tax ID Number
- • State issued document with your organization's Resale Tax ID Number
- • City or County issued Business License
- • State Department of Health Services License
- • Any other ID issued by the State that includes the business name & address
* ATTN: California Customers may require additional documentation as part of the CA Health & Safety Code. Products that fall under this regulation will be placed on a mandatory 21-day hold after documentation is received. Avantor will not lift restrictions for residential shipping addresses.
Specifications
- Protein/Peptide Type:Recombinant
- Source:HEK293 cells
- Species:Human
- Size:0.01 mg
- Environmentally Preferable:
- Tag sequence:Tag free
- Biological Activity:Measured by its binding ability in a functional ELISA. Immobilized ActiveMax® Human VEGF165 at 2 ug/mL can bind Human VEGF R1, His Tag with a linear range of 3-50 ng/mL.
- Protein Synonyms:RP1-261G23.1|MVCD1|MGC70609|VEGFA|VEGF165|VPF
- Protein/Peptide Name:VEGF-1651
- Purity:>98% as determined by SDS-PAGE of reduced (+) and non-reduced (-) rhVEGF165.
- Molecular Weight:19 kDa (monomer)
- Formulation:Lyophilized, PBS, pH7.4
- Tested Applications:Western Blot
- Cat. No.:10797-928
- Supplier no.:96-772
Specifications
About this item
VEGF165 is the most abundant splice variant of VEGF-A. VEGF165 is produced by a number of cells including endothelial cells, macrophages and T cells. VEGF165 is involved in angiogenesis, vascular endothelial cell survival, growth, migration and vascular permeability. VEGF gene expression is induced by hypoxia, inflammatory cytokines and oncogenes. VEGF165 binds to heparan sulfate and is retained on the cell surface and in the extracellular matrix. VEGF165 binds to the receptor tyrosine kinases, VEGFR1 and VEGFR2. VEGF165 is the only splice variant that binds to co-receptors NRP-1 and NRP-2 that function to enhance VEGFR2 signaling. Binding of VEGF165 to VEGFR1 and VEGFR2 leads to activation of the PI3K/AKT, p38 MAPK, FAK and paxillin. VEGF plays a key role in tumor angiogenesis in many cancers.