About this item
Interleukin 33 (IL-33) is a member of the IL-1 cytokine family and is constitutively expressed in smooth muscle and airway epithelial cells. IL-33 signals through the interleukin 1 receptor-like 1 (IL-1R1) and interleukin-1 receptor accessory protein (IL1RAP) receptors to ativate NF-κB and MAPK signaling pathways. IL-33 functions to induce type 2 cytokine production in polarized Type 2 helper T (Th2) cells.
Shenandoah Biotechnology is a manufacturer of research grade recombinant proteins typically used as cytokines, growth factors and chemokines in cell based assays and cell culture. Each production lot is tested for QA and the expected values for each product can be viewed under the product specifications tab.
A COA is supplied with each product shipped detailing purity, formulation, biological activity, endotoxin levels, reconstitution instructions and recommended storage conditions. This product is for research use only and is not for use in humans.
Specifications
- Conjugation:Unconjugated
- Protein Function:Cytokine
- Protein/Peptide Type:Recombinant
- Source:E. coli
- Species:Human
- Storage Conditions:–20 °C
- Endotoxin Content:Endotoxin LAL (EU/µg) ≤0.1
- Biological Activity:Bioactivity assay: D10S cell proliferation, ED50 ≤0.5 ng/ml, Bioactivity ≥2.0×10⁶ units/mg
- Gene ID:O95760
- Reconstitution Instructions:Sterile water at 0.1 mg/ml
- Endotoxin-free:N
- Carrier-Free:Y
- Protease-free:N
- Animal-Free:N
- Protein Synonyms:NP-HEV
- Protein/Peptide Name:IL-33
- Purity:≥95%
- Molecular Weight:18.1 kDa
- Sequence:MSITGISPIT EYLASLSTYN DQSITFALED ESYEIYVEDL KKDEKKDKVL LSYYESQHPS NESGDGVDGK MLMVTLSPTK DFWLHANNKE HSVELHKCEK PLPDQAFFVL HNMHSNCVSF ECKTDPGVFI GVKDNHLALI KVDSSENLCT ENILFKLSET
- Endotoxin Level:Low
- Formulation:10 mM sodium phosphate, pH 7.5
- Nuclease-free:N
- Grade:RUO
- Shipping Temperature:RT
- Tested Applications:Bioassay