About this item
Interferon gamma (IFNγ) is a type II interferon that is critical during adaptive and innate immune responses to infection. IFNγ is produced by T cells and natural killer cells following antigen-specific activation. IFNγ binds IFNγ receptors (IFNγR1 and IFNγR2), which are expressed on most immune cells, to activate the JAK-STAT pathway. IFNγ-induced signaling increases the expression of class 1 major histocompatibility complex (MHC) molecules. Human IFNγ is not cross-reactive with mouse IFNγ.
Shenandoah Biotechnology is a manufacturer of research grade recombinant proteins typically used as cytokines, growth factors and chemokines in cell based assays and cell culture. Each production lot is tested for QA and the expected values for each product can be viewed under the product specifications tab.
A COA is supplied with each product shipped detailing purity, formulation, biological activity, endotoxin levels, reconstitution instructions and recommended storage conditions. This product is for research use only and is not for use in humans.
Specifications
- Conjugation:Unconjugated
- Protein Function:Cytokine
- Protein/Peptide Type:Recombinant
- Source:E. coli
- Species:Human
- Storage Conditions:–20 °C
- Endotoxin Content:Endotoxin LAL (EU/µg) ≤0.1
- Biological Activity:Bioactivity assay: Viral challenge assay using EMC virus on A549 cells, ED50 ≤0.75 ng/ml, Bioactivity ≥1.3×10⁶ units/mg
- Gene ID:P01579
- Reconstitution Instructions:Sterile water at 0.1 mg/ml
- Endotoxin-free:N
- Carrier-Free:Y
- Protease-free:N
- Animal-Free:N
- Protein Synonyms:Type II interferon|T cell interferon|MAF|Immune Interferon
- Protein/Peptide Name:IFNg
- Purity:≥95%
- Molecular Weight:16.9 kDa
- Sequence:MQDPYVKEAE NLKKYFNAGH SDVADNGTLF LGILKNWKEE SDRKIMQSQI VSFYFKLFKN FKDDQSIQKS VETIKEDMNV KFFNSNKKKR DDFEKLTNYS VTDLNVQRKA IHELIQVMAE LSPAAKTGKR KRSQMLFQGR RASQ
- Endotoxin Level:Low
- Formulation:10 mM sodium phosphate, 50 mM sodium chloride, pH 7.5
- Nuclease-free:N
- Grade:RUO
- Shipping Temperature:RT
- Tested Applications:Bioassay
Specifications
Related Information
Certificates
Search by Lot NumberLiterature reference - PubMed ID 24280128 Literature reference - PubMed ID 26306596 Literature reference - PubMed ID 28242024 Literature reference - PubMed ID 28656178 Literature reference - PubMed ID 29399392
Additional Product Details
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