Primary Human Dermal Lymphatic Endothelial Cells (HDLEC) are a subpopulation of the Human Dermal Endothelial Cells. They are isolated from the dermis of juvenile foreskin and adult skin (different locations) from a single donor.
(Human Dermal Blood Endothelial Cells (HDBEC) from the same donor are available on request.) The cells are routinely analyzed by flow cytometric analysis and immunofluorescent staining: > 95% of the cells are CD31 positive  and podoplanin positive. In addition, the cells stain positive for Prox-1.

Lymphatic vessels transport excess fluids from tissues to the circulatory system and are a major component of the immune system

This product can be used in the following applications. Angiogenesis research, Oncology, Drug uptake studies, Cell-cell junction investigation, Inflammation studies.

The transported fluid is nearly cell free. The vessels are highly permeable, because they lack a continuous basal membrane. Lymphatic endothelial cells are involved in pathological alterations of the lymphatic system. During tumor lymphangiogenesis, the lymphatic endothelial cells build new vessels that infiltrate tumors, attract tumor cells, and induce tumor cell metastasis.