Specifications
- Antibody Type:Primary
- Antigen Name:Cytotoxic T-lymphocyte-Associated Protein 4
- Antigen Symbol:CTLA4
- Clone:UC10-4F10-11
- Flow Cytometry:Yes
- Host:Armenian hamster
- Isotype:IgG
- Reactivity:Mouse
- Size:100 µg
- Neutralisation:Yes
- Gene ID:12477
- Antigen Synonyms:IDDM12|GRD4|GSE|CD|CTLA-4|ALPS5|cytotoxic T-lymphocyte associated protein 4|CD152|CELIAC3
- Storage Temperature:Store undiluted at 2-8°C, protect from light, do not freeze.
- Tested Applications:Functional Assay
- Cat. No.:10141-170
- Supplier no.:40-1522-U100
Specifications
About this item
The UC10-4F10-11 antibody is specific for mouse CD152, commonly known as CTLA-4, a 33-37 kDa protein expressed as a homodimer on the surface of activated T and B cells, and on thymocytes. CTLA-4 is structurally similar, yet functionally disparate, to the T cell co-stimulatory molecule CD28. Both CTLA-4 and CD28 interact with the co-stimulatory molecules CD80 (B7-1) and CD86 (B7-2) on antigen-presenting cells, with CTLA-4 displaying a higher avidity than CD28. While CD28 typically delivers a potent co-stimulatory signal in support of T cell activation, CTLA-4 appears to act as a negative regulator of T cell activation and may contribute to the suppressor function of Treg cells.
CTLA-4 proteins may be initially sequestered within Golgi vesicles, from which they can be rapidly transferred to and from the cell surface, a mechanism by which Treg cells can selectively impart suppressive functions. The UC10-4F10-11 antibody may be used for flow cytometric analysis of CTLA-4 expression.
Type: Primary
Antigen: CTLA4
Clonality: 0
Clone: UC10-4F10-11
Conjugation:
Epitope:
Host: Armenian Hamster
Isotype:
Reactivity: