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Human Recombinant PEDF (from E. coli)
Human Recombinant PEDF (from E. coli)
  10072-802
 :  Prosci
 :  
Human Recombinant PEDF (from E. coli)
  10072-802
 :  Prosci
 :  40-233
 :  

 

  • Protein/Peptide Type:
    Recombinant
  • Source:
    E. coli
  • Species:
    Human
  • Size:
    0.005 mg
  • Gene ID:
    5176
  • Protein Synonyms:
    Cell proliferation-inducing gene 35 protein|PEDF|PIG35|OI12|OI6|EPC-1|Pigment epithelium-derived factor
  • Protein/Peptide Name:
    PEDF
  • Purity:
    >90%
  • Formulation:
    Lyophilized
  • Cat. No.:
    10072-802
  • Supplier no.:
    40-233

 

 

PEDF is a noninhibitory serpin with neurotrophic, anti-angiogenic, and anti-tumorigenic properties. It is a 50 kDa glycoprotein produced and secreted in many tissues throughout the body. A major component of the anti-angiogenic action of PEDF is the induction of apoptosis in proliferating endothelial cells. In addition, PEDF is able to inhibit the activity of angiogenic factors such as VEGF and FGF-2. The neuroprotective effects of PEDF are achieved through suppression of neuronal apoptosis induced by peroxide, glutamate, or other neurotoxins. The recent identification of a lipase-linked cell membrane receptor for PEDF (PEDF-R) that binds to PEDF with high affinity (1) should facilitate further elucidation of the underlying mechanisms of this pluripotent serpin. To date, PEDF-R is the only signaling receptor known to be used by a serpin family member. The unique range of PEDF activities implicate it as a potential therapeutic agent for the treatment of vasculature related neurodegenerative diseases such as age-related macular degeneration (AMD) and proliferative diabetic retinopathy (PDR). PEDF also has the potential to be useful in the treatment of various angiogenesis-related diseases including a number of cancers. Recombinant PEDF is a 44.5 kDa non-glycosylated protein containing 400 amino acid residues. (1) Notari, I. et al. J Biol Chem., Vol. 281, 38022-38037.

Store in working aliquots at -20°C. Avoid freeze/thaw cycles.