- Antibody Type:Primary
- Antigen Name:microtubule-associated protein tau
- Antigen Symbol:Mapt
- Clonality:Polyclonal
- Conjugation:Unconjugated
- Host:Rabbit
- Reactivity:Chicken,Human,Bovine,Rat,Mouse
- Western Blot:Yes
- Size:0.1 mL
- Form:Liquid
- Gene ID:P19332
- Antigen Synonyms:Mapt
- Modification:Ser 416
- Storage Buffer:100 uL in 10 mM HEPES (pH 7.5), 150 mM NaCl, 100 ug per mL BSA and 50% glycerol.
- Molecular Weight:59/65/68
- Storage Temperature:Tau (Ser416) antibody can be stored at –20 °C and is stable at –20 °C for at least 1 year.
- Shipping Temperature:4 °C
- Immunogen:Phosphopeptide corresponding to amino acid residues surrounding the phospho-Ser416 of rat tau.
- Purification:Affinity Purified
- Cat. No.:10075-424
- Supplier no.:50-270
Tau is a key microtubule-associated protein that plays an important role in the formation of microtubules in axons (Binder et al. 1985). Six tau isoforms have been identified as products of a single gene produced by alternative mRNA splicing (Goedert 1990). Tau mutations have been implicated in many neurodegenerative disorders such as Alzheimer’s disease (AD), Pick’s disease and progressive supranuclear palsy. It has been well documented that hyperphosphorylated tau is a major component of paired helical filaments in AD brain (Lee 1995). Serine 416 has been demonstrated to be a major phosphorylation site in vitro by CaM kinase II (Steiner at al. 1990).
Affinity Purified
100 uL in 10 mM HEPES (pH 7.5), 150 mM NaCl, 100 ug per mL BSA and 50% glycerol.
Aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.
Type: Primary
Antigen: Mapt
Clonality: Polyclonal
Clone:
Conjugation: Unconjugated
Epitope:
Host: Rabbit
Isotype:
Reactivity: Human, Mouse, Rat, Bovine, Chicken