- Antibody Type:Primary
- Antigen Name:receptor (TNFRSF)-interacting serine-threonine kinase 1
- Antigen Symbol:RIPK1
- Clonality:Polyclonal
- Conjugation:Unconjugated
- ELISA:Yes
- Host:Rabbit
- ImmunoChemistry:Yes
- Isotype:IgG
- Reactivity:Human
- Size:0.1 mg
- Form:Liquid
- Gene ID:Q13546
- Antigen Synonyms:RIPK1
- Storage Buffer:RIPK1 Antibody is supplied in PBS containing 0.02% sodium azide.
- Molecular Weight:Predicted: 74 kDa
- Storage Temperature:RIPK1 antibody can be stored at 4 °C for three months and –20 °C, stable for up to one year.
- Concentration:1 mg/mL
- Shipping Temperature:4 °C
- Immunogen:RIPK1 antibody was raised against a 14 amino acid peptide near the carboxy terminus of human RIP1. The immunogen is located within amino acids 600 - 650 of RIPK1.
- Purification:RIPK1 Antibody is affinity chromatography purified via peptide column.
- Cat. No.:10062-546
- Supplier no.:3291
RIP1 Antibody: RIP1 (Receptor Interacting Protein), also known as RIPK1, is a crucial 74 kD adaptor kinase in several of stress-induced signaling pathways and on the crossroad of a cell’s decision to live or die. RIP1 contains an N-terminal region with homology to protein kinases, an intermediate domain capable of association with MAPKKK and a C-terminal region containing a death domain motif present in the Fas and TNFR1 intracellular domains. Full length RIP1 is important for signallling to NF-kappa-B, MAPKs and necrosis, whereas caspase-8 generates a C-terminal RIP1 cleavage fragment, promoting TNF-induced apoptosis. It is required for TNFRSF1A-mediated and TLR3-induced NF-kappa-B activation. RIP1-deficient mice fail to thrive, displaying extensive apoptosis in both lymphoid and adipose tissues and dying at 1-3 days of age.
RIP1 antibody can be used for detection of RIP1 by immunohistochemistry at 5 - 10 ?g/mL.
RIP1 Antibody is affinity chromatography purified via peptide column.
RIP1 Antibody is supplied in PBS containing 0.02% sodium azide.
Aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.
Type: Primary
Antigen: RIPK1
Clonality: Polyclonal
Clone:
Conjugation: Unconjugated
Epitope:
Host: Rabbit
Isotype: IgG
Reactivity: Human