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- Antibody Type:Primary
- Antigen Name:tyrosine kinase 2
- Antigen Symbol:TYK2
- Clonality:Monoclonal
- Clone:8G8E9 / 8G9H5
- Conjugation:Unconjugated
- ELISA:Yes
- Host:Mouse
- Isotype:IgG1
- Reactivity:Human
- Western Blot:Yes
- Size:0.1 mL
- Gene ID:P29597
- Antigen Synonyms:TYK2
- Storage Buffer:Ascitic fluid containing 0.03% sodium azide.
- Storage Temperature:Tyk2 monoclonal antibody can be stored at –20 °C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
- Shipping Temperature:4 °C
- Immunogen:Ni-NTA purified truncated recombinant Tyk2 expressed in E. Coli strain BL21 (DE3).
- Cat. No.:10070-704
- Supplier no.:32-232
Tyk2 (tyrosine kinase 2),with 1187-amino acid protein (about 131 kDa), belongs to the family of non-receptor janus tyrosine kinases, which also includes Jak1, Jak2, and Jak3. Kinases of the Jak family regulate a spectrum of cellular functions downstream of activated cytokine receptors in the lympho-hematopoietic system. Tyk2 is activated by a variety of cytokines: IFN-beta, IFN-beta, IL-6, IL-10, IL-12, and IL-13 and promotes IFN-gamma production by Th1-type CD4 cells. Tyk2 can be viewed as a dual-function Jak, mediating both pro-inflammatory and anti-inflammatory cytokine responses. Tyk2 is also an important regulator of lymphoid tumor surveillance.
Western Blot:1:500 - 1:2,000
ELISA:Propose dilution 1:10,000.
Determining optimal working dilutions by titration test.
Ascitic fluid containing 0.03% sodium azide.
Aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.
Type: Primary
Antigen: TYK2
Clonality: Monoclonal
Clone: 8G8E9 / 8G9H5
Conjugation: Unconjugated
Epitope:
Host: Mouse
Isotype: IgG1
Reactivity: Human