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Specifications
- Antibody Type:Primary
- Antigen Name:discoidin domain receptor tyrosine kinase 2
- Antigen Symbol:DDR2
- Clonality:Monoclonal
- Clone:3B11E4
- Conjugation:Unconjugated
- ELISA:Yes
- Host:Mouse
- ImmunoChemistry:Yes
- Isotype:IgG2a
- Reactivity:Human
- Western Blot:Yes
- Size:0.1 mL
- Environmentally Preferable:
- Gene ID:Q16832
- Antigen Synonyms:DDR2
- Storage Buffer:Ascitic fluid containing 0.03% sodium azide.
- Storage Temperature:DDR2 monoclonal antibody can be stored at –20 °C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
- Shipping Temperature:4 °C
- Immunogen:Ni-NTA purified truncated recombinant DDR2-Trx expressed in E. Coli strain BL21 (DE3).
- Cat. No.:10073-228
- Supplier no.:32-144
Specifications
About this item
DDR2 (discoidin domain receptor family, member 2) is one of the largest families of proteins in eukaryotes. The family has been classified in 8 major groups based on sequence comparison of their tyrosine (PTK) or serine/ threonine (STK) kinase catalytic domains. Receptor tyrosine kinases (RTKs) play a key role in the communication of cells with their microenvironment. These molecules are involved in the regulation of cell growth, differentiation, and metabolism. In several cases the biochemical mechanism by which RTKs transduce signals across the membrane has been shown to be ligand induced receptor oligomerization and subsequent intracellular phosphorylation. This autophosphorylation leads to phosphorylation of cytosolic targets as well as association with other molecules, which are involved in pleiotropic effects of signal transduction. RTKs have a tripartite structure with extracellular, transmembrane, and cytoplasmic regions. This gene encodes a member of a novel subclass of RTKs and contains a distinct extracellular region encompassing a factor VIII-like domain. Alternative splicing in the 5' UTR results in multiple transcript variants encoding the same protein.
Western Blot:1:500 - 1:2,000
IHC(P):1:500 - 1:2,000
ELISA:Propose dilution 1:10,000.
Determining optimal working dilutions by titration test.
Ascitic fluid containing 0.03% sodium azide.
Aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.
Type: Primary
Antigen: DDR2
Clonality: Monoclonal
Clone: 3B11E4
Conjugation: Unconjugated
Epitope:
Host: Mouse
Isotype: IgG2a
Reactivity: Human