Anti-DCP2 Rabbit Polyclonal Antibody
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Product Details & Documents
DCP2 is necessary for the degradation of mRNAs, both in normal mRNA turnover and in nonsense-mediated mRNA decay. DCP2 removes the 7-methyl guanine cap structure from mRNA molecules, yielding a 5'-phosphorylated mRNA fragment and 7m-GDP. It has higher activity towards mRNAs that lack a poly (A) tail, but has no activity towards a cap structure lacking a RNA moiety.DCP2 is a key component of an mRNA-decapping complex required for removal of the 5-prime cap from mRNA prior to its degradation from the 5-prime end (Fenger-Gron et al., 2005 [PubMed 16364915]).
DCP2 antibody can be used for detection of DCP2 by ELISA at 1:62500. DCP2 antibody can be used for detection of DCP2 by western blot at 0.5 ?g/mL, and HRP conjugated secondary antibody should be diluted 1:50,000 - 100,000.
Antibody is purified by peptide affinity chromatography method.
Antibody is lyophilized in PBS buffer with 2% sucrose. Add 50 ?L of distilled water. Final antibody concentration is 1 mg/mL.
Aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.
Type: Primary
Antigen: DCP2
Clonality: Polyclonal
Clone:
Conjugation: Unconjugated
Epitope:
Host: Rabbit
Isotype:
Reactivity: Human
Documents
10108-436.pdf
Datasheet
Specifications
- Size:100 ul
- Clonality:Polyclonal
- Molecular Weight:48 kDa
- Purification:Antibody is purified by peptide affinity chromatography method.
- Form:Liquid
- Storage Buffer:Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
- Host:Rabbit
- Cat. No.:10108-436
- Reactivity:Human
- Western Blot:Yes
- Shipping Temperature:4 °C
- Antibody Type:Primary
- Antigen Symbol:DCP2
- Gene ID:Q8IU60
- Immunogen:Antibody produced in rabbits immunized with a synthetic peptide corresponding a region of human DCP2.
- Conjugation:Unconjugated
- Antigen Synonyms:DCP2
- Antigen Name:decapping mRNA 2
- ELISA:Yes
- Storage Temperature:For short periods of storage (days) store at 4 °C. For longer periods of storage, store DCP2 antibody at –20 °C. As with any antibody avoid repeat freeze-thaw cycles.
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