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Anti-CASP8 Rabbit Polyclonal Antibody
  89415-804
 :  Prosci
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Anti-CASP8 Rabbit Polyclonal Antibody
  89415-804
 :  Prosci
 :  3475

 

  • Antibody Type:
    Primary
  • Antigen Name:
    caspase 8, apoptosis-related cysteine peptidase
  • Antigen Symbol:
    CASP8
  • Clonality:
    Polyclonal
  • Conjugation:
    Unconjugated
  • ELISA:
    Yes
  • Host:
    Rabbit
  • Isotype:
    IgG
  • Reactivity:
    Human,
    Mouse
  • Western Blot:
    Yes
  • Size:
    0.1 mg
  • Form:
    Liquid
  • Gene ID:
    Q14790
  • Antigen Synonyms:
    CASP8
  • Storage Buffer:
    Caspase-8 Antibody is supplied in PBS containing 0.02% sodium azide.
  • Storage Temperature:
    Caspase-8 antibody can be stored at 4 °C for three months and –20 °C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
  • Concentration:
    1 mg/mL
  • Shipping Temperature:
    4 °C
  • Immunogen:
    Caspase-8 antibody was raised against a 15 amino acid synthetic peptide from near the carboxy terminus human caspase-8 isoform E. The immunogen is located within the last 50 amino acids of Caspase-8.
  • Tested Applications:
    E, WB
  • Purification:
    Caspase-8 Antibody is affinity chromatography purified via peptide column.
  • Cat. No.:
    89415-804
  • Supplier no.:
    3475

 

 

Caspase-8 Antibody: Caspases are a family of cysteine proteases that can be divided into the apoptotic and inflammatory caspase subfamilies. Unlike the apoptotic caspases, members of the inflammatory subfamily are generally not involved in cell death but are associated with the immune response to microbial pathogens. The apoptotic subfamily can be further divided into initiator caspases, which are activated in response to death signals, and executioner caspases, which are activated by the initiator caspases and are responsible for cleavage of cellular substrates that ultimately lead to cell death. Caspase-8 is an initiator caspase that was identified as a member of the Fas/APO-1 death-inducing signaling complex. The adaptor molecule FADD couples procaspase-8 to the Fas receptor death domain; subsequent oligomerization promotes procaspase-8 autoactivation. FLIP, a catalytically inactive caspase-8-like molecule inhibits these interactions and thus can inhibit apoptosis. This antibody will only detect isoform E of caspase-8.

Type: Primary
Antigen: CASP8
Clonality: Polyclonal
Clone:
Conjugation: Unconjugated
Epitope:
Host: Rabbit
Isotype: IgG
Reactivity: Human, Mouse