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Anti-PMAIP1 Rabbit Polyclonal Antibody
Anti-PMAIP1 Rabbit Polyclonal Antibody
Catalog # 89415-474
Supplier:  Prosci
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Anti-PMAIP1 Rabbit Polyclonal Antibody
Catalog # 89415-474
Supplier:  Prosci
Supplier Number:  2437

Specifications

  • Antibody Type:
    Primary
  • Antigen Name:
    phorbol-12-myristate-13-acetate-induced protein 1
  • Antigen Symbol:
    Pmaip1
  • Clonality:
    Polyclonal
  • Conjugation:
    Unconjugated
  • ELISA:
    Yes
  • Host:
    Rabbit
  • ImmunoChemistry:
    Yes
  • ImmunoFluorescence:
    Yes
  • Isotype:
    IgG
  • Reactivity:
    Human,
    Rat,
    Mouse
  • Western Blot:
    Yes
  • Size:
    0.1 mg
  • Form:
    Liquid
  • Gene ID:
    Q9JM54
  • Antigen Synonyms:
    Pmaip1
  • Storage Buffer:
    Noxa Antibody is supplied in PBS containing 0.02% sodium azide.
  • Storage Temperature:
    Noxa antibody can be stored at 4 °C for three months and –20 °C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
  • Concentration:
    1 mg/mL
  • Shipping Temperature:
    4 °C
  • Immunogen:
    Noxa antibody was raised against a synthetic peptide corresponding to 17 amino acids at the amino terminus of mouse Noxa. The immunogen is located within the first 50 amino acids of Noxa.
  • Tested Applications:
    E, WB, IHC, IF
  • Purification:
    Noxa Antibody is immunoaffinity chromatography purified IgG.
  • Cat. No.:
    89415-474
  • Supplier no.:
    2437

Specifications

About this item

Noxa Antibody: Apoptosis is related to many diseases and development. The p53 tumor-suppressor protein induces apoptosis through transcriptional activation of several genes including p53R2, p53AIP1, and PUMA. A new p53 target gene, Noxa, was recently identified, which encodes a protein belonging to the subfamily of BH3-only proapoptic proteins. Noxa and PUMA are both transcriptional targets of p53 and BH3-only proteins. X-ray irradiation increased p53-dependent Noxa mRNA and protein levels. Noxa, when ectopically expressed, interacted with anti-apoptotic Bcl-2 family members, resulting in the activation of caspase-9. Noxa, like PUMA, localized to mitochondria and induces apoptosis in response to p53. Noxa and PUMA may represent direct mediators of p53-induced apoptosis. Increased levels of p53 and its target gene Noxa was found in the impaired tumor development.

Type: Primary
Antigen: Pmaip1
Clonality: Polyclonal
Clone:
Conjugation: Unconjugated
Epitope:
Host: Rabbit
Isotype: IgG
Reactivity: Human, Mouse, Rat