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- Assay Type (ELISA with LOV):Sandwich
- Primary antibody reactivity:Human
- Target protein:BAFF (soluble)
- Description:BAFF, soluble (human) ELISA kit (hypersensitive)
- Size:1 Kit
- Sample Type:Cell Culture Supernatant, Plasma, Serum
- Cross Reactivity:Does not detect mouse BAFF
- Detection Method:Colorimetric
- Detection Range:0.0156 to 1 ng/ml
- Storage Temperature:+4 °C
- Sensitivity:8 pg/ml
- Cat. No.:102515-630
- Supplier no.:AG45B0001KI01
BAFF (B cell-activating factor; BLyS; B lymphocyte stimulator; TNFSF13B; TALL-1; CD257), belonging to the TNF family, is a master regulator of peripheral B cell survival, and together with IL-6, promotes Ig class-switching and plasma cell differentiation
BAFF co-stimulates activated T cells. Increased levels of soluble BAFF have been detected in the serum of patients with various autoimmune diseases, such as Sjögren's syndrome, rheumatoid arthritis, multiple sclerosis and systemic lupus erythematosus (SLE). Furthermore, BAFF is found in inflammatory sites in which there is lymphoid neogenesis. BAFF levels are elevated in patients with multiple myeloma and B cell chronic lymphoid leukemia (B-CCL).