About this item
APRIL is a cytokine that belongs to the TNF superfamily and binds to TACI and BCMA. It is implicated in the regulation of tumor cell growth, is involved in monocyte/macrophage-mediated immunological processes and functions as an important survival factor for plasmablasts and bone marrow plasma cells. MultimericAPRIL™ is a high activity construct in which two trimeric APRIL ligands are artificially linked via the collagen domain of ACRP30. This construct very effectively stimulates proliferation B cell. A basic amino acid sequence (QKQKKQ) close to the N-terminus of APRIL is required for binding to negatively charged sulfated glycosaminoglycan side chains of proteoglycans. Proteoglycans mediate binding of APRIL to tumor cells as well as primary lymphoid cells.
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Specifications
- Conjugation:Unconjugated
- Protein/Peptide Type:Recombinant
- Source:HEK293 cells
- Species:Human
- Storage Conditions:–20 °C
- Endotoxin Content:<0.01EU/µg
- Biological Activity:Stimulates B cell proliferation.
- Gene ID:O75888
- Protein Synonyms:ACRP30headless:TNFSF13|MultimericAPRIL™|ACRP30headless:APRIL|ACRP30headless:A-proliferation-inducing Ligand:|ACRP30headless:CD256
- Protein/Peptide Name:Megaapril
- Purity:95%
- Molecular Weight:~34kDa (SDS-PAGE)
- Sequence:16-108
- Endotoxin Level:Low
- Concentration:0.1mg/ml after reconstitution.
- Formulation:Lyophilized. Contains PBS + 0.5% Trehalose.
- Shipping Temperature:-20 °C, Blue Ice