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- Conjugation:Unconjugated
- Protein/Peptide Type:Recombinant
- Source:HEK293 cells
- Species:Human
- Size:50 µg
- Storage Conditions:–20 °C
- Endotoxin Content:<0.05EU/µg
- Gene ID:Q9H665
- Protein Synonyms:Transmembrane Protein 149|IGF-like Family Receptor 1|U2 Small Nuclear RNA Auxiliary Factor 1-like 4|TMEM149
- Protein/Peptide Name:IGFLR1
- Purity:95%
- Molecular Weight:~50kDa (SDS-PAGE)
- Sequence:23-154
- Endotoxin Level:Low
- Concentration:1mg/ml after reconstitution.
- Formulation:Lyophilized. Contains PBS.
- Shipping Temperature:-20 °C, Blue Ice
- Cat. No.:102515-578
- Supplier no.:AG40B0087C050
Insulin-growth factor-like gene family is a new family of proteins consisting of four proteins in humans (IGFL1 to 4) and one in mice (mIGFL). mIGFL is expressed in normal skin in mice and further upregulated during inflammation responses in skin or after skin wounding. In human only IGFL1 expression is increased in psoriatic skin samples. mIGFL and human IGFL1 and 3 interact with specificity and high affinity to a novel receptor named IGF-like family receptor 1 (formerly TMEM-149). Analysis of the amino acid sequence of IGFLR1 indicated that this receptor is likely a novel member of the TNF-R family. IGFLR1 is expressed most abundantly on mouse T cells, suggesting that mIGFL and IGFL1 produced in the skin may potentially exert regulatory functions on T cell responses.