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- Antibody Type:Primary
- Antigen Name:Retinoic Acid-inducible Gene 1
- Antigen Symbol:RIG-1
- Clonality:Monoclonal
- Clone:Alme-1
- Conjugation:Biotin
- ImmunoChemistry:Yes
- ImmunoPrecipitation:Yes
- Isotype:IgG1
- Reactivity:Human,Mouse
- Western Blot:Yes
- Size:100 µg
- Form:Liquid
- Gene ID:O95786
- Antigen Synonyms:Probable ATP-dependent RNA Helicase DDX58|DEAD-box Protein 58|RIG-1|Retinoic Acid-inducible Gene 1 Protein
- Storage Buffer:In PBS containing 0.02% sodium azide.
- Storage Temperature:Short term: +4 °C, Long Term: –20 °C
- Concentration:0.5mg/ml
- Shipping Temperature:-20° C
- Immunogen:Recombinant human RIG-I (aa 201-713).
- Cat. No.:102514-270
- Supplier no.:AG20B0009BC100
RIG-I and MDA5 are highly conserved helicases involved in the innate immune response to virus. RIG-I is a member of the DEAD-box RNA helicases and is activated by cytoplasmic dsRNA and 5'-ppp RNA produced during the viral replication. The protein is characterized by a N-terminal region with two caspase recruitment domains (CARD) and a C-terminal region harboring potential ATP-dependent RNA helicase activity. RIG-I recruits the CARD adaptor inducing IFN-beta (Cardif) in a CARD-CARD-dependent manner resulting in NF-kappaB and IRF3 activation.
- Stable for at least 1 year after receipt when stored at -20°C.
Purified from concentrated hybridoma tissue culture supernatant.
Purity: >95% (SDS-PAGE)
Type:
Antigen: RIG-I
Clonality: Monoclonal
Clone: Alme-1
Conjugation: Biotin
Epitope:
Host: Mouse
Isotype: IgG1
Reactivity: Human, Mouse