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Human Recombinant IL-35:Fc
Human Recombinant IL-35:Fc
Catalog # 89151-952
Supplier:  Enzo Life Sciences
CAS Number:  
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Human Recombinant IL-35:Fc
Catalog # 89151-952
Supplier:  Enzo Life Sciences
Supplier Number:  522-140-C010
CAS Number:  
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Specifications

  • Protein/Peptide Type:
    Recombinant
  • Species:
    Human
  • Size:
    10 µg
  • Endotoxin Content:
    <0.1EU/µg purified protein (LAL test; Lonza).
  • Biological Activity:
    Inhibits human mononuclear cell proliferation.
  • Reconstitution Instructions:
    Reconstitute with 100µl sterile water. Further dilutions should be made with medium containing 5% fetal calf serum or a carrier protein.
  • Protein/Peptide Name:
    IL-35:Fc
  • Purity:
    >95% (SDS-PAGE)
  • Concentration:
    0.1mg/ml after reconstitution.
  • Formulation:
    Lyophilized. Contains PBS.
  • Cat. No.:
    89151-952
  • Supplier no.:
    522-140-C010

Specifications

About this item

Produced in HEK 293 cells. Human EBI3 (aa 21-229) linked to human IL-12A (aa 23-219) via the linker GGGSGGGSGGGSGGGS is fused at the C-terminus to the Fc portion of human IgG1 and a FLAG®-tag.

EBI3 (Epstein-Barr virus-induced gene 3 protein; EBV-induced gene 3 protein; IL-27B; IL-27 subunit β) and IL-12A (IL-12 subunit p35; CLMF p35) form the heterodimeric cytokine IL-35 (interleukin-35) involved in T cell regulation. IL-35 is highly expressed in regulatory T cell (Treg) but not in effector or naive T cells. IL-35 is required for the suppressive function of T-reg in vitro and in vivo.