Acetyl-(D-Arg¹⁰,Cys¹¹,D-Phe¹⁴,Cys¹⁷)-beta-MSH (10-17) Amide Trifluoroacetate

Highly potent and selective β-MSH-derived melanocortin-4 receptor (MC-4R) agonist with sub-nanomolar potency. The binding affinities for human MC-4R, MC-1R, MC-3R and MC-5R were 0.55 ± 0.06, 16.78 ± 1.53, 56.79 ± 4.66, and < 500 nM, respectively. Daily subcutaneous injection of H-6268 to diet-induced obese rats over a period of 14 days demonstrated an effect on reduction of fat mass.

CAS No.:
819048-44-7
Storage Conditions:
–20 ± 5 °C
MDL No.:
MFCD18782384
Protein/Peptide Name:
Acetyl-(D-Arg¹⁰,Cys¹¹,D-Phe¹⁴,Cys¹⁷)-beta-MSH (10-17) amide Trifluoroacetate
Molecular Weight:
1175.36
Sequence:
Ac-D-Arg-Cys-Glu-His-D-Phe-Arg-Trp-Cys-NH₂
Molecular Formula:
C₅₁H₇₀N₁₈O₁₁S₂