This glycoprotein functions as both an antihemophilic factor carrier and a platelet-vessel wall mediator in the blood coagulation system. Important in the maintenance of homeostasis, it participates in platelet-vessel wall interactions by forming a noncovalent complex with coagulation factor VIII at the site of vascular injury. The von Willebrand factor has functional binding domains to platelet glycoprotein Ib, glycoprotein IIb/IIIa, collagen and heparin. Mutations in this gene or deficiencies in this protein result in von Willebrand's disease. VWD is characterized by frequent bleeding (gingival, minor skin quantitative lacerations, menorrhagia, etc.).

No further titration is required. We suggest an incubation period of 30-60 minutes at RT. However, depending upon the fixation conditions and the staining system employed, optimal incubation should be determined by the user. Proteolytic treatment is recommended before immunostaining. Not tested in other applications. Optimal dilutions/concentrations should be determined by the researcher.

Type: Primary
Antigen: VWF
Clonality: Monoclonal
Clone: F8/86
Conjugation: Unconjugated
Epitope:
Host: Mouse
Isotype: IgG1
Reactivity: Human