Colchicine

Supplier: Thermo Scientific Chemicals

Colchicine 97%

Supplier: Thermo Scientific Chemicals

Colchicine, dry 95% (dry weight)

Supplier: Enzo Life Sciences

Inhibitor of tubulin polymerization

Supplier: Thermo Scientific Chemicals

Microtubule disrupting agent, and induces apoptosis in human lymphoma cells

Supplier: TCI America

CAS Number: 64-86-8
MDL Number: MFCD00078484
Molecular Formula: C22H25NO6
Molecular Weight: 399.44
Purity/Analysis Method: >97.0% (HPLC)
Form: Crystal
Melting point (°C): 150
Specific rotation [a]20/D: -238 deg (C=1, EtOH)

Supplier: Abcam

Inhibitor of microtubule formation (Ki = 2.1 μM). Antimitotic, anti-inflammatory and antifibrotic activity. Unable to cross the blood-brain barrier.

Supplier: MilliporeSigma

Inhibitor of mitosis used in cell division studies.

Supplier: Aladdin Scientific

Colchicine, a tubulin Inhibitor, has been shown to block polymerization of microtubules by binding to tubulin. Studies indicate that this reagent also causes apoptosis of cells by acting on tissue plasminogen activators (tPA) and disrupting the cytoskeleton of cells. Exposure of cells to Colchicine has also been reported to result in alterations of Ca²⁺ concentrations in cells which may also result in apoptosis.

Supplier: Aladdin Scientific

Colchicine, a tubulin Inhibitor, has been shown to block polymerization of microtubules by binding to tubulin. Studies indicate that this reagent also causes apoptosis of cells by acting on tissue plasminogen activators (tPA) and disrupting the cytoskeleton of cells. Exposure of cells to Colchicine has also been reported to result in alterations of Ca²⁺ concentrations in cells which may also result in apoptosis. A mitosis inhibitor useful in cell division studies.

Supplier: Aladdin Scientific

Product DescriptionColchicine is a tricyclic alkaloid that can stay in circulation for 20 to 40 hours post intake. Leucocytes harbour maximum colchicine.

Supplier: BeanTown Chemical

CAS: 64-86-8; EC No: 200-598-5; MDL No: MFCD00078484; RTECS: GH0700000 UN No: UN1544; Haz Class: 6.1; Packing Group: I Powder; Molecular Formula: C22H25NO6; MW: 399.44 Melting Point: 150-160° (decomposes) Light Sensitive

Supplier: USP

(300 mg)

Supplier: Matrix Scientific

Colchicine ≥95%

Supplier: R&D Systems

Inhibitor of tubulin

Supplier: Adipogen

Binds specifically with tubulin thus interfering with microtubule organization.

Supplier: Adipogen

Anti-cancer compound. Microtubule assembly inhibitor. Depolymerizes microtubules and limits microtubule formation (inactivates spindle fibre formation). Inhibits mitosis during cell division at metaphase by inhibiting spindle formation. Anti-inflammatory compound. Suppresses monosodium urate crystal-induced NLRP3/NALP3 inflammasome-driven caspase-1 activation, IL-1beta processing and release, and L-selectin expression on neutrophils at micromolar concentrations. Blocks the release of a crystal-derived chemotactic factor from neutrophil lysosomes, blocks neutrophil adhesion to, and inhibits monosodium urate crystal-induced production of superoxide anions from neutrophils at nanomolar concentrations. Drug used in treatment of gout, familial Mediterranean fever, pericarditis and Behect's disease. Investigated for its anti-cancer activity. It has a narrow therapeutic index with no clear-cut distinction between nontoxic, toxic and lethal doses, causing substantial confusion among clinicians. Apoptosis inducer in a variety of normal and tumor cell lines. Inhibitor of autophagosome-lysosome fusion. Inhibits acetylated a-tubulin mediated dynein dependent transport of mitochondria and subsequent apposition of ASC on mitochondria to NLRP3 on the endoplasmic reticulum in vitro and in vivo.