You searched for: PPP
PPP ≥98% (by HPLC)
Supplier: Enzo Life Sciences
A potent and selective inhibitor of insulin-like growth factor 1 receptor (IGF-1R, IC50=6 nM). It efficiently blocks IGF-1R activity, reduces pAKT and pERK1/2, induces apoptosis in IGF-1R-positive tumor cells and causes complete tumor regression in xenografted and allografted mice. Picropodophyllin downregulates IGF-1R by interfering with the action of β-arrestin 1/MDM2. It causes tumor regression and attenuates invasiveness of uveal melanoma cells. It displays beneficial effects on tumor growth, angiogenesis, bone disease and survival in a mouse multiple myeloma model. It attenuates intimal hyperplasia after vascular injury. Inhibition of IGF-1R is non-competitive with ATP.
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PPP
Supplier: Thermo Scientific Chemicals
Picropodophyllotoxin is an insulin-like growth factor-I (IGF-I) receptor kinase inhibitor
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PPP 98%
Supplier: Ambeed
(5R,5aS,8aR,9R)-9-Hydroxy-5-(3,4,5-trimethoxyphenyl)-5,8,8a,9-tetrahydrofuro[3',4':6,7]naphtho[2,3-d][1,3]dioxol-6(5aH)-one, Purity: 98%, CAS Number: 477-47-4, Appearance: Form: solid, Storage: Sealed in dry, 2-8 C, Size: 1mg