N-Hydroxy-N'-phenyloctanediamide
N-Hydroxy-N'-phenyloctanediamide 98%
Supplier: Thermo Scientific Chemicals
N-Hydroxy-N'-phenyloctanediamide 98%
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N-Hydroxy-N'-phenyloctanediamide
Supplier: Abcam
Potent non-selective HDAC inhibitor (IC₅₀ values are 10 and 20 nM for HDAC1 and HDAC3, respectively). Induces apoptosis and shows antiproliferative effects against cancer cell lines (IC₅₀ = 3 - 8 μM). Antitumor effects in vivo. No effect on class III HDACs. Orally active.
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N-Hydroxy-N'-phenyloctanediamide 98%
Supplier: Ambeed
N-Hydroxy-N'-phenyloctanediamide 98%
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N-Hydroxy-N'-phenyloctanediamide
Supplier: Adipogen
Vorinostat (SAHA, MK0683, Zolinza) inhibits the enzymatic activity of histone deacetylases HDAC1, HDAC2 and HDAC3 (Class I) and HDAC6 (Class II) at nanomolar concentrations (IC50 86 nM). These enzymes catalyze the removal of acetyl groups from the lysine residues of histones proteins. In some cancer cells, there is an overexpression of HDACs, or an aberrant recruitment of HDACs to oncogenic transcription factors causing hypoacetylation of core nucleosomal histones. By inhibiting histone deacetylase, vorinostat causes the accumulation of acetylated histones and induces cell cycle arrest and/or apoptosis of some transformed cells. The mechanism of the antineoplastic effect of vorinostat has not been fully characterized.
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