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DAPT
Supplier: Thermo Scientific Chemicals
A cell-permeable dipeptide that suppresses A_x001A_ production by blocking _x001A_-secretase
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DAPT ≥98% (by NMR)
Supplier: Adipogen
Cell permeable gamma-secretase inhibitor (IC50 = 115 nM for total beta-amyloid, IC50 = 200 nM for beta-amyloid 1-42). Reduces Abeta levels in vivo. Blocks the proteolytic processing of neurotrophin receptor alike death domain protein (NRADD). Does not inhibit persenilinase. Notch processing inhibitor. Enhances neuronal differentiation independent of sonic hedgehog (Shh) signaling. CDK5 activity inhibitor. Apoptosis enhancer.
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