Supplier: Bioss

Comprising more than ten subunits, the anaphase-promoting complex (APC) acts in a cell-cycle dependent manner to promote the separation of sister chromatids during the transition between metaphase and anaphase in mitosis. APC, or cyclosome, accomplishes this progression through the ubiquitination of mitotic cyclins and other regulatory proteins that are targeted for destruction during cell division. APC is phosphorylated, and thus activated, by protein kinases Cdk1/cyclin B and polo-like kinase (Plk). APC is under tight control by a number of regulatory factors, including CDC20, CDH1 and MAD2. Specifically, CDC20 and CDH1 directly bind to APC and activates APC’s cyclin-ubiquitination activity. In contrast, MAD2 inhibits APC by forming a ternary complex with CDC20 and APC; thus preventing APC activation. APC11 is a RING-H2 finger protein that allows for the synthesis of multiubiquitin chains in the presence of Ubiquitin carrier protein 4 (Ubc4) and ubiquitin conjugating enzyme (E2). In addition, a heterodimeric complex of either Ubc4 or UbcH10 with APC11 and APC2 catalyzes the ubiquitination of human securin and cyclin B1.

Supplier: DuPont

These hooded coveralls, model IC193BWH TS, are made of Tyvek®, a fabric composed of flash spun high density polyethylene, providing an ideal balance of protection, durability and comfort. Tyvek® is permeable to both air and water vapour, yet repels water-based liquids and aerosols. It offers an excellent barrier against fine particles and fibres (down to 1 µm in size).

Supplier: Bioss

IGSF11 is also known as BTIGSF (brain and testis-specific immunoglobulin superfamily protein) or VSIG3 (V-set and immunoglobulin domain-containing protein 3) and is a 431 amino acid protein that is expressed as three isoforms. IGSF11 is highly expressed in testis and ovary and is also expressed in brain, kidney and skeletal muscle, localized to the cellular membrane as a single-pass membrane protein. IGSF11 is an immunoglobulin with V-type and C2-type domains that function in molecular recognition. When IGSF11 is in the trans position, it plays an important role in cell-cell adhesion via both homophilic and heterophilic interactions with other molecules. These cell–cell interactions are also thought to be important for neuronal cell interactions, such as neuron–neuron or neuron–glia interactions, which are important for the development and function of the central nervous system. In addition, IGSF11 might also be involved interactions between Sertoli cells and spermatocytes, which are important associations during spermatogenesis. The IGSF11 gene is commonly upregulated in gastric cancer and IGSF11 is highly expressed in many types of human tumors, indicating that it may be useful as a target for immunotherapy.

Supplier: Thermo Fisher Scientific

Armadillo™ 384-well PCR plates combine the rigidity of a polycarbonate frame with thin walled polypropylene wells to provide superior thermal cycling performance under all conditions, without warping. All formats are available with clear or white wells, ensuring the highest level of sensitivity for all PCR and qPCR reactions.

Supplier: Brady

Mark cables and wires with the B-427 self-laminating vinyl label material, designed with a clear self-laminating protective layer. Print almost anywhere with a durable Brady portable label printer.

Supplier: Bioss

IGSF11 is also known as BTIGSF (brain and testis-specific immunoglobulin superfamily protein) or VSIG3 (V-set and immunoglobulin domain-containing protein 3) and is a 431 amino acid protein that is expressed as three isoforms. IGSF11 is highly expressed in testis and ovary and is also expressed in brain, kidney and skeletal muscle, localized to the cellular membrane as a single-pass membrane protein. IGSF11 is an immunoglobulin with V-type and C2-type domains that function in molecular recognition. When IGSF11 is in the trans position, it plays an important role in cell-cell adhesion via both homophilic and heterophilic interactions with other molecules. These cell–cell interactions are also thought to be important for neuronal cell interactions, such as neuron–neuron or neuron–glia interactions, which are important for the development and function of the central nervous system. In addition, IGSF11 might also be involved interactions between Sertoli cells and spermatocytes, which are important associations during spermatogenesis. The IGSF11 gene is commonly upregulated in gastric cancer and IGSF11 is highly expressed in many types of human tumors, indicating that it may be useful as a target for immunotherapy.

Supplier: Bioss

IGSF11 is also known as BTIGSF (brain and testis-specific immunoglobulin superfamily protein) or VSIG3 (V-set and immunoglobulin domain-containing protein 3) and is a 431 amino acid protein that is expressed as three isoforms. IGSF11 is highly expressed in testis and ovary and is also expressed in brain, kidney and skeletal muscle, localized to the cellular membrane as a single-pass membrane protein. IGSF11 is an immunoglobulin with V-type and C2-type domains that function in molecular recognition. When IGSF11 is in the trans position, it plays an important role in cell-cell adhesion via both homophilic and heterophilic interactions with other molecules. These cell–cell interactions are also thought to be important for neuronal cell interactions, such as neuron–neuron or neuron–glia interactions, which are important for the development and function of the central nervous system. In addition, IGSF11 might also be involved interactions between Sertoli cells and spermatocytes, which are important associations during spermatogenesis. The IGSF11 gene is commonly upregulated in gastric cancer and IGSF11 is highly expressed in many types of human tumors, indicating that it may be useful as a target for immunotherapy.

Supplier: Thermo Fisher Scientific

Meet your certification and documentation needs with our level 2 Thermo Scientific™ SureSTART™ specification certified screw vial and cap kits. Select level 2 products for high throughput applications, when robustness and reproducibility are key.

Supplier: Showa

These low linting nylon/acrylic knitted gloves have anti-static properties. The conductive Thunderon® fibre covers the important area of the fingers, providing static discharge by corona effect. The gloves are available without coating, with PU coating on fingertips only, and with coating on fingertips and palm.

Supplier: FRISTADS KANSAS

These overalls consist of different fabric combinations. The fluorescent material is water repellent and manufactured from 80% polyester and 20% cotton. The other parts are made of 65% polyester and 35% cotton with a soft nap on reverse. The reinforcement is made from 100 % polyamide.

Supplier: FRISTADS KANSAS

Functional, two-tone winter jacket made from Beaver nylon (50% nylon, 50% cotton), a hard-wearing and tear-proof material that is resistant to dirt, oil and water. With faux fur on the collar and on the body, quilted lining in the sleeves and contrasting seams.

Supplier: ProSci Inc.

WBP11 is a nuclear protein, which colocalizes with mRNA splicing factors and intermediate filament-containing perinuclear networks. WBP11has 95% amino acid sequence identity to the mouse Wbp11 protein. It contains two proline-rich regions that bind to the WW domain of Npw38, a nuclear protein, and thus this protein is also called Npw38-binding protein NpwBP. The Npw38-NpwBP complex may function as a component of an mRNA factory in the nucleus.This gene encodes a nuclear protein, which colocalizes with mRNA splicing factors and intermediate filament-containing perinuclear networks. This protein has 95% amino acid sequence identity to the mouse Wbp11 protein. It contains two proline-rich regions that bind to the WW domain of Npw38, a nuclear protein, and thus this protein is also called Npw38-binding protein NpwBP. The Npw38-NpwBP complex may function as a component of an mRNA factory in the nucleus.

Supplier: MILLIPORE

These centrifugal filter units can be used for a number of applications: concentration of biological samples containing antigens, antibodies, enzymes, nucleic acids, or microorganisms; purification of macromolecular components found in tissue culture extracts or cell lysates and protein removal prior to HPLS; concentration of dilute or pre-purified proteins from column eluents; desalting, buffer exchange and protein dialysis; size exclusion and protein fractionation.

Supplier: FRISTADS KANSAS

Dirt, oil and water repellent trousers with inherent flame protection adapted for ATEX environments with no metal details. Manufactured from 45% modacrylic, 35% cotton, 18% polyamide and 2% anti-static fibre. Approved for industrial laundry.

Supplier: ProSci Inc.

SHP2 Antibody: Src homology-2 domain containing protein (SHP2) is a member of the protein tyrosine phosphatase (PTP) family, a protein family that contains signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. SHP2 contains two tandem Src homology-2 (SH2) domains, which function as phosphotyrosine binding domains either directly or through scaffolding intermediates such as the insulin-receptor substrate 1 (IRS-1). These SH2 domains mediate the interaction of SHP2 with its substrates, allowing SHP2 to dephosphorylate proteins that inhibit signaling kinases such as ERK1 and AKT. SHP2 is widely expressed in most tissues and plays a regulatory role in various cell signaling events that are important for a diversity of cell functions, such as mitogenic activation, metabolic control, transcription regulation, and cell migration. Recent experiments have shown SHP2 plays a significant role in hepatoprotection and liver regeneration.

Supplier: 3M

The 3M Speedglas Heavy-Duty Welding Helmet G5-01 builds on the 9100 series. Having more adjustable features than ever - from the colour as seen through the welding filter to the direction of the airflow and the level of coverage.

Supplier: SIOEN

This water- and windproof jacket is made of anti-static Siopor FR AST fabric: 100% polyester fabric with 100% FR PU coating + AST. It features a fixed flame-retardant cotton lining with one pocket.

Supplier: SIOEN

Water- and windproof overall made of Flexothane® Classic: 100% polyamide knitting with PU coating. With fixed quilted lining, knitted wind cuffs in sleeves and high frequency welded seams.

Supplier: SIOEN

Waterproof and windproof rain jacket made of Siopor® Extra: 100% polyester fabric (cotton touch) with 100 % PU laminate. The fabric is water repellent on the outside and moisture attracting on the inside. With fixed mesh lining in body and hood and polyamide lining in sleeves.

Supplier: Portwest

Jacket made of 300D Oxford Weave polyester with a stain resistant finish and PU coating. With detachable fur lining and wadding for additional cold protection.

Supplier: FRISTADS KANSAS

Thanks to its durability and high degree of comfort, the PR54 jacket is perfectly suited to workshops and industrial and service enterprises. The material is made from 65% polyester and 35% cotton. The inside is brushed and as a result conveys a pleasantly comfortably cotton feeling. The outside is also resistant to the roughest demands and will not fade even after countless washes.

Supplier: FRISTADS KANSAS

Thanks to their durability and comfort, these trousers are perfectly suited to workshops, and industrial and service enterprises. The material is made from 65% polyester and 35% cotton. The inside is brushed, ensuring a pleasantly comfortable cotton feel. The outside can withstand the roughest demands and will not fade, even after countless washes.

Supplier: FRISTADS KANSAS

Thanks to their durability and comfort, these trousers are perfectly suitable for use in garages as well as in industrial and service companies. The material is made of 65% polyester and 35% cotton. The inside is brushed and provides a comfortable cotton feel. The outside is very hardwearing and does not bleach, even after countless washes.

Supplier: VWR Collection

Compact stirrers with a ceramic glass plate provide excellent chemical resistance. Units feature digital error code display, a 'hot' top indicator to warn users that surface is hot, a fixed safety circuit that shuts off the heater if temperature rises above 550 °C, and three operating modes to choose from (standard, safe and adjustment protection). Stirrers have a speed display scale and optional capability to connect directly to a PT1000 temperature sensor; when using this functionality, control accuracy in the medium is ±0,5 °C.

Supplier: Avantor

J.T.Baker® Endonuclease Ultrapure Bioreagent is designed for the degradation of both single stranded and double stranded DNA and RNA. J.T.Baker® Endonuclease Ultrapure Bioreagent is used to ensure host cell DNA impurities are removed; driving process efficiency by lowering viscosity and preventing aggregation. J.T.Baker® Endonuclease is an enzyme based upon the native endonuclease of Serratia marcescens, enabling rapid clearance of residual DNA and RNA during the production and purification of both recombinant proteins and viral vectors. Non-animal origin. The purity of materials in non-negotiable. J.T.Baker® Endonuclease Ultrapure Bioreagent acts to degrade and eliminate extraneous genetic material, ensuring the pristine quality of your final product.

Supplier: FRISTADS KANSAS

Thanks to their durability and comfort, these trousers are perfectly suitable for use in garages as well as in industrial and service companies. The material is made of 65% polyester and 35% cotton. The inside is brushed and provides a comfortable cotton feel. The outside is very hardwearing and does not bleach, even after countless washes.

Supplier: FRISTADS KANSAS

These trousers are manufactured from the hardwearing FLAM fabric, made from a flame retardant 75/25 cotton/polyester blend. The trousers provide protection against open flames as well as against electrical arcs.

Supplier: Portwest

PW3 Hi-Vis baffle features HiVisTex Pro reflective tape for greater freedom of movement. The polyester ripstop outer combined with lightweight Insulatex thermal insulation offers an ultrasoft, water resistant solution for outdoor wear. Clever features include Ezee zip fastening and zipped pockets for secure storage.

Supplier: Sartorius

These filter tips have more space between the sample and the filter than conventional filter tips. This virtually eliminates the risk of an expensive or a contagious sample permeating the filter.

Supplier: MILLIPORE

These centrifugal filter units can be used for a number of applications: concentration of biological samples containing antigens, antibodies, enzymes, nucleic acids, or microorganisms; purification of macromolecular components found in tissue culture extracts or cell lysates and protein removal prior to HPLC; concentration of dilute or pre-purified proteins from column eluents; desalting, buffer exchange and protein dialysis; size exclusion and protein fractionation.