49548 Results for: "Pier\\u015Bcienie+do+osadzania&pageNo=8"
15(S)-Hydroxyeicosa-5Z,8Z,11Z,13E-tetraenoic acid (HETE) ≥99% (by HPLC)
Supplier: Enzo Life Sciences
Biosynthesis in human neutrophils, eosinophils and reticulocytes. Most abundant eicosanoid in human bronchi. Regulates T lymphocyte mitogenesis. Induces immunosupression. Stimulates migration of capillary endothelial cells and neovascularisation.
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Chaetocin ≥98% (by TLC)
Supplier: Enzo Life Sciences
Methyltransferase inhibitor
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12(S)-Hydroxy-(5Z,8Z,10E,14Z)-eicosatetraenoic acid 50 µg/ml in ethanol ≥98% (by HPLC)
Supplier: Enzo Life Sciences
Biosynthesis by platelet 12-lipoxygenase. Chemotactic and chemokinetic for PMNL2 and for vascular smooth muscle cells. Antiproliferative effect on smooth muscle cells. Second messenger in angiotensin induced aldosterone production. Induces endothelial cell retraction and tumor cell adhesion.
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24(S),25-Epoxycholesterol ≥98% (by TLC)
Supplier: Enzo Life Sciences
LXR ligand.
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WAY-200070 ≥98% (by TLC)
Supplier: Enzo Life Sciences
Estrogen receptor ligand.
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2,3-Bis(4-hydroxyphenyl)propionitrile ≥98% (by TLC), white solid
Supplier: Enzo Life Sciences
Estrogen receptor β activator.
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Dihydroergocristine methanesulphonate ≥98%, white solid
Supplier: Enzo Life Sciences
Serotonin receptor ligand.
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Melatonin ≥98% (by HPLC)
Supplier: Enzo Life Sciences
Endogenous agonist at melatonin MT1 and MT2 receptors. Displays antioxidant and antiapoptotic effects in numerous cell types as well as beneficial effects in various neurodegenerative diseases. It protects neuronal cells from amyloid beta-mediated oxidative damage and increases survival in an Alzheimer’s disease transgenic mouse model. Melatonin directly inhibits mitochondrial permeability transition pore (IC50 = 0.8M) and reduced the loss of neurons in a rat model of transient brain ischemia.
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α-Hydroxyalprazolam ≥98% (by TLC)
Supplier: Enzo Life Sciences
Metabolite of alprazolam.
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Lidocaine-N-ethyl bromide ≥98% (by TLC), white solid
Supplier: Enzo Life Sciences
Na+ channel blocker
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MBCQ ≥98%
Supplier: Enzo Life Sciences
Selective inhibitor of cGMP-specific phosphodiesterase (PDE V, IC50=19 nM).
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Quazinone ≥98% (by HPLC)
Supplier: Enzo Life Sciences
Selective inhibitor of cGMP-inhibited phosphodiesterase (PDE III, IC50=0.6µM).
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BML-244 ≥98% (by TLC)
Supplier: Enzo Life Sciences
A highly potent, cell-permeable inhibitor of cathepsin K (IC50=51 nM).
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H-7 dihydrochloride ≥98% (by TLC)
Supplier: Enzo Life Sciences
Inhibits PKA (Ki=3.0μM), PKG (Ki=5.8μM), MLCK (Ki=97μM) and PKC (Ki=6μM). Also inhibits myosin light chain kinase. Induces apoptotic DNA fragmentation and cell death. Inhibits telomerase activity in treated NPC-076 cells. Cell permeable.
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Baicalein ≥98% (by TLC)
Supplier: Enzo Life Sciences
Lipoxygenase inhibitor
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D-erythro-Sphingosine ≥98% (by TLC)
Supplier: Enzo Life Sciences
Common component of cell membranes, often as phosphatidyl conjugates. Is a potent (IC50=1-3 µM) and selective inhibitor of protein kinase C. Inhibition is competitive with diacylglycerol, phorbol dibutyrate and Ca2+ and it also inhibits PKC activation by other lipids. It acts on an equimolar basis with 1,2-dioleoylglycerol and does not affect other kinases such as MLCK and PKA. It is active in intact cells and has been identified as an endogenous constituent in HL-60 cells, neutrophils, rat liver, and brain and mouse tissues. Other activities include inhibition of phosphatidate phosphohydrolase, Na+,K+-ATPase, CTP:phosphocholine cytidylyltransferase, calmodulin-dependent enzymes, binding of factor VII to tissue factor, binding of thyrotropin releasing hormone to its receptor and activation of EGF receptor kinase, phospholipase D and casein kinase II.
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7-Ethoxyresorufin ≥98%
Supplier: Enzo Life Sciences
Cytochrome P450 substrate
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Tyrphostin AG-126 ≥98% (by HPLC)
Supplier: Enzo Life Sciences
AG-126 prevents lipopolysaccharide-induced lethal toxicity (septic shock) in mice. Administered at 1.5 mg/mouse, it reduced LPS-induced lethal toxicity from 95% to 10%. AG-126 greatly reduces LPS-induced tyrosine phosphorylation of p42MAPK in murine peritoneal macrophages at 50 µM. EGFR, Her-2/neu receptor or PDGF-R are not inhibited at 100 µM. Inhibits tyrosine kinase-dependent B cell receptor signaling.
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MK-886 ≥98% (by HPLC)
Supplier: Enzo Life Sciences
Inhibitor of PPARα activation. Inhibits 5-lipoxygenase-activating protein (FLAP) and leukotriene biosynthesis. Binds to FLAP with high affinity and prevents the activation of 5-lipoxygenase. IC50’s for leukotriene biosynthesis: 2.5 nM in intact leukocytes; 1.1 µM in whole blood. Induces apoptosis through the mitochondrial pathway.
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HNMPA-(AM)3 ≥98% (by TLC)
Supplier: Enzo Life Sciences
HNMPA-(AM)3 is a cell-permeable analog of HNMPA. It inhibits insulin receptor tyrosine kinase activity (IC50=100 µM) and insulin-stimulated glucose oxidation in isolated rat adipocytes (IC50=10 µM). It has no effect on PKA (at concs. up to 1 mM) or PKC (at concs. up to 420 µM). Inhibits both serine and tyrosine autophosphorylation by the human insulin receptor. Does not affect protein kinase C (PKC) or cAMP-dependent protein kinase (PKA).
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K-252b ≥98% (by HPLC)
Supplier: Enzo Life Sciences
General, cell permeable protein kinase inhibitor. Acts by binding to the ATP binding domain of the kinase. Potent inhibitor of Ca2+/calmodulin kinase II. Inhibits myosin light chain kinase (MLCK; Ki=0.147µM), cAMP- dependent protein kinase (PKA; Ki=0.09µM), protein kinase C (PKC; Ki=0.02µM), and cGMP-dependent protein kinase (PKG; Ki=0.1µM).
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Sp-5,6-dichloro-cBIMPS ≥98% (by HPLC)
Supplier: Enzo Life Sciences
PKA activator.
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SB216763 ≥98% (by TLC)
Supplier: Enzo Life Sciences
Potent and selective inhibitor of GSK-3β (IC50=34nM). Stimulates glycogen synthesis in human liver cells and mimics other actions of insulin. Protects primary neurons from death induced by PI-3 kinase pathway inhibition suggesting therapeutic potential in neurodegenerative diseases and stroke. Reduces pulmonary inflammation and fibrosis in a mouse model.
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Sodium 4-phenylbutyrate ≥98% (by UHPLC)
Supplier: Enzo Life Sciences
Weak histone deacetylase (HDAC) inhibitor. Induces differentiation, growth arrest and apoptosis in a number of cell lines. Protects against cerebral ischemic injury and displays neuroprotective effect in a mouse model of Huntington’s disease. Anti-neoplastic agent and transcriptional regulator. Also acts as an inducer of tumor cytostasis and differentiation. Shows chemical chaperone activity.
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2,3-Bis(2-hydroxyethylthio)-1,4-naphthalenedione ≥98% (by HPLC)
Supplier: Enzo Life Sciences
A potent and selective inhibitor of Cdc25 phosphatase (Ki's for Cdc25A, B and C are 32, 96 and 40 nM respectively). NSC-95397 inhibits the growth of several human tumor cell lines and blocks G2/M cell cycle transition.
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Ar231453 ≥98% (by HPLC), yellow solid
Supplier: Enzo Life Sciences
GPR119 activator.
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Supplier: GRANT INSTRUMENTS
Supplier: BOCHEM
Supplier: VWR Collection
Supplier: OMEGA BIO-TEK
Supplier: DWK Life Sciences
Supplier: Thermo Fisher Scientific
Supplier: VWR Collection
Supplier: Oxford Nanopore Technologies
Supplier: Integra
Supplier: Industrial Physics
Supplier: AAT BIOQUEST
Supplier: Integra
Supplier: Palbam
Supplier: VWR Collection
Supplier: VWR Collection
Supplier: FACELLITATE
Supplier: NANOENTEK
Supplier: Greiner Bio-One