54829 Results for: "Markery,+d\u0142ugopisy+i+grawery&pageNo=48"

Supplier: Bioss

Receptor for thyrothropin. Plays a central role in controlling thyroid cell metabolism. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Also acts as a receptor for thyrostimulin (GPA2+GPB5).

Supplier: Bioss

Spindly/CCDC99

Supplier: Bioss

Binds fibroblast growth factor and E-selectin (cell-adhesion lectin on endothelial cells mediating the binding of neutrophils).

Supplier: Bioss

SH3KBP1 belongs to the CIN85/CMS family of adaptor molecules, characterized by containing three N-terminal Src homology domains, a proline rich region and a C-terminal coiled-coil domain. The different members of the family orchestrate a network involved in dowregulation and degradation of recpetor tyrosine kinases. SH3KBP1 is involved in regulating diverse signal transduction pathways. Involved in the regulation of endocytosis and lysosomal degradation of ligand-induced receptor tyrosine kinases, including EGFR and MET/hepatocyte growth factor receptor, through a association with CBL and endophilins. In the case of EGF receptor turnover, its activation involves recruitment of SH3KBP1- endophilin complexes to mediate internalization. Once internalized, RTKs are delivered into the endosomal compartment where receptors get sorted for either recycling back to the cell surface or are targeted to lysosomes for degradation. Alternate splicing results in multiple transcript variants.

Supplier: Bioss

The Hox homeobox genes encode proteins that are transcriptional regulators with an established role in embryonic development. HoxC5 is a 222 amino acid protein that localizes to the nucleus and contains one homeobox DNA-binding domain. Existing as multiple alternatively spliced isoforms, HoxC5 functions as a sequence-specific DNA-binding transcription factor that is part of a regulatory mechanism that provides cells with positional identities during development. The gene encoding HoxC5 maps to a cluster of Hox proteins on chromosome 12 that are essential for morphogenesis. Encoding over 1,100 genes within 132 million bases, chromosome 12 makes up about 4.5% of the human genome. A number of skeletal deformities are linked to chromosome 12, including hypochondrogenesis, achondrogenesis and Kniest dysplasia.

Supplier: Bioss

NAP125, also known as NCKAP1 (NCK-associated protein 1), p125Nap1 or membrane-associated protein HEM-2, is a 1,128 amino acid single pass membrane protein that exists as two alternatively spliced isoforms and belongs to the HEM-1/HEM-2 family. While widely expressed, NAP125 is found at highest levels in heart, brain and skeletal muscle where it regulates Rac-dependent actin remodeling as part of a lamellipodial complex with WAVE2, Abi-1 and CYFIP1. NAP125 localizes to the cytoplasmic side of lamellipodium membrane and is encoded by a gene that maps to human chromosome 2q32.1 and mouse chromosome 2 C3. NAP125 expression is markedly reduced in Alzheimer disease (AD)-affected brains, suggesting a possible role in the disease.

Supplier: Bioss

This is a receptor for calcitonin. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. The calcitonin receptor is thought to couple to the heterotrimeric guanosine triphosphate-binding protein that is sensitive to cholera toxin.

Supplier: Thermo Fisher Scientific

Indium gallium alloy (60:40 w%) ≥99.99% (metals basis)

Supplier: Thermo Fisher Scientific

3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) 98%

Supplier: Thermo Fisher Scientific

Silica gel, granules ACS -6+18 Mesh desiccant, with indicator

Supplier: PanReac AppliChem

Acrylamide : Bisacrylamide (37.5:1) 40% in aqueous solution, 4x crystallised

Supplier: Thermo Fisher Scientific

Cerium(III)-2-ethylhexanoate 49% (12% Ce) in 2-ethylhexanoic acid

Supplier: Trajan Scientific and Medical

Vespel/graphite GC ferrules are made from quality polyimide/graphite blend. They seal with minimal torque and can be reused and repositioned along capillary columns if not over compressed in the fitting. Due to slight shrinking at high temperatures, they must be retightened after initial temperature cycles to avoid leaks.

Supplier: Abcam

PE Rabbit monoclonal [EPR22592-18] to DLL3.

Supplier: Apollo Scientific

6-Bromo-3,4-dihydro-1H-[1,8]naphthyridin-2-one 97%

Supplier: Abcam

Anti-D Amino Acid Oxidase Rabbit Monoclonal Antibody [clone: EPR25838-43]

Supplier: Abcam

PE Rabbit monoclonal [EPR23494-47] to CCR2.

Supplier: Abcam

APC Rabbit monoclonal [EPR23845-44] to CXCR3.

Supplier: Abcam

PE Rabbit monoclonal [EPR22811-18] to CD105.

Supplier: Abcam

Alexa Fluor® 488 Mouse monoclonal [87G] to HLA G.

Supplier: Abcam

Alexa Fluor® 488 Mouse monoclonal [3G3] to FOXP3.

Supplier: Abcam

Alexa Fluor® 488 Rabbit monoclonal [EPR6855] to CD4.

Supplier: Thermo Fisher Scientific

Sodium borohydride 12% in sodium hydroxide solution 40%, AcroSeal®

Supplier: Abcam

Alexa Fluor® 488 Mouse monoclonal [PC10] to PCNA.

Supplier: Abcam

Alexa Fluor® 488 Mouse monoclonal [Rat-401] to Nestin.

Supplier: Abcam

Alexa Fluor® 488 Rabbit monoclonal [Y72] to ERK1.

Supplier: Abcam

Alexa Fluor® 488 Mouse monoclonal [7F7AB10] to AIF.

Supplier: US Biological

Anti-IgG, Fc Rabbit Polyclonal Antibody (DyLight® 488)

Supplier: Bioss

Ubiquitination is an important mechanism through which three classes of enzymes act in concert to target short-lived or abnormal proteins for destruction. The three classes of enzymes involved in ubiquitination are the ubiquitin-activating enzymes (E1s), the ubiquitin-conjugating enzymes (E2s) and the ubiquitin-protein ligases (E3s). MARCH3 (membrane-associated ring finger (C3HC4) 3), also known as RNF173, is a 253 amino acid multi-pass membrane protein that localizes to cytoplasmic vesicles and early endosomes and contains one RING-CH-type zinc finger. Involved in the pathway of protein modification, MARCH3 functions as an E3 ubiquitin-protein ligase that accepts a ubiquitin residue from an E2 ubiquitin-conjugating enzyme and is thought to be involved in endosomal trafficking events.

Supplier: Bioss

The cerebral and vascular plaques associated with Alzheimer's disease are mainly composed of Amyloid beta peptides. beta Amyloid is derived from cleavage of the Amyloid precursor protein and varies in length from 39 to 43 amino acids. beta Amyloid [1-40], beta Amyloid [1-42], and beta Amyloid [1-43] peptides result from cleavage of Amyloid precursor protein after residues 40, 42, and 43, respectively. The cleavage takes place by gamma-secretase during the last Amyloid precursor protein processing step. beta Amyloid [1-40], beta Amyloid [1-42], and beta Amyloid [1-43] peptides are major constituents of the plaques and tangles that occur in Alzheimer's disease. beta Amyloid and peptides have been developed as tools for elucidating the biology of Alzheimer's disease.