52542 Results for: "Intrinsic+factor"

Supplier: Antibodies.com

Mouse monoclonal [KIT/983] antibody to c-Kit for WB with samples derived from human.

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Mouse monoclonal [MCM7/1467] antibody to MCM7 for flow cytometry, IF and IHC-P with samples derived from human.

Supplier: Antibodies.com

Recombinant rabbit monoclonal [DM181] antibody to BAFF for ELISA and Flow cytometry with samples derived from human.

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Recombinant mouse monoclonal [rMACIF/7288] antibody to CD59 for IHC-P with samples derived from human.

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Rabbit polyclonal antibody to ETS1 (phospho Thr38) for WB, IHC, IF and ELISA with samples derived from Human, Mouse and Rat.

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Recombinant mouse monoclonal [rEGFR/6389] antibody to EGFR for IHC-P with samples derived from human.

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Mouse monoclonal [31G7 + GFR1195] antibody to EGFR for flow cytometry, IF and IHC-P with samples derived from human.

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Mouse monoclonal [PCRP-KLF12-1E3] antibody to KLF12 for IP, Flow Cytometry and IF with samples derived from human.

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Rabbit polyclonal antibody to PKR for WB, IHC and ELISA with samples derived from human.

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Rabbit monoclonal [ARC2439] antibody to EG-VEGF for WB and ICC/IF with samples derived from Human, Mouse and Rat.

Supplier: ProSci Inc.

FAS is a receptor and contains three TNFR-Cys repeats and one death domain. It has been shown that FAS is involved in the physiological regulation of programmed cell death, and has been implicated in the pathogenesis of various malignancies and diseases of the immune system. FADD (adapter molecule) recruits caspase-8 to the activated receptor, the resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases mediating apoptosis. FAS-mediated apoptosis may play a role in the induction of peripheral tolerance, in the antigen-stimulated suicide of mature T-cells, or both.

Supplier: ProSci Inc.

Acts as a transcriptional regulator. Inhibits myogenesis by sequestrating E proteins, inhibiting trans-activation by MEF2, and inhibiting DNA-binding by MYOD1 through physical interaction. This interaction probably involves the basic domains of both proteins. Also represses expression of proinflammatory cytokines such as TNFA and IL1B. Regulates cranial suture patterning and fusion. Activates transcription as a heterodimer with E proteins. Regulates gene expression differentially, depending on dimer composition. Homodimers induce expression of FGFR2 and POSTN while heterodimers repress FGFR2 and POSTN expression and induce THBS1 expression. Heterodimerization is also required for osteoblast differentiation.

Supplier: ProSci Inc.

IL-2 is a powerful immunoregulatory lymphokine produced by T-cells in response to antigenic or mitogenic stimulation. IL-2/IL-2R signaling is required for T-cell proliferation and other fundamental functions which are essential for the immune response. IL-2 stimulates growth and differentiation of B-cells, NK cells, lymphokine activated killer cells, monocytes, macrophages and oligodendrocytes. Recombinant murine IL-2 is a 17.2 kDa protein, containing 149 amino acid residues. Recombinant rat IL-2 is a 15.3 kDa protein containing 134 amino acid residues. Recombinant human IL-2 is a 15.5 kDa protein, containing 134 amino acid residues including one intrachain disulfide bond.

Supplier: ProSci Inc.

CD55 is a member of the RCA (regulators of complement activation) family. RCA proteins is characterized by the presence of four to 30 SCRs (short consensus repeats also called CCPs for control protein modules) in their plasmaexposed regions. CD55 containing four SCR modules is involved in the regulation of the complement cascade. CD55 is known to bind CD97 via the first SCR. It also binds physiologically generated C3 convertases with its second and third SCRs. Binding results in an accelerated “decay”, or dissociation of active C3 convertases, thus blocking the development of C’ attack complexes on nonforeign cells. It is known that viruses and bacteria also utilize multiple SCR sites for infection.

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Rabbit polyclonal antibody to STAT1 (phospho Ser727) for WB, IHC and ELISA with samples derived from Human, Mouse and Rat.

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Recombinant rabbit monoclonal [STAT6/7774R] antibody to STAT6 for IHC-P with samples derived from human.

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Rabbit polyclonal antibody to M-CSF Receptor (phospho Tyr809) for WB and ELISA with samples derived from Human, Mouse and Rat.

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Mouse monoclonal [MCM7/1467] antibody to MCM7 for Flow Cytometry, IF and IHC-P with samples derived from Human.

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Mouse monoclonal [PCRP-HOMEZ-1B5] antibody to HOMEZ for flow cytometry and IHC-P with samples derived from human.

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Mouse monoclonal [PCRP-ELK1-1D9] antibody to ELK1 for WB and IF with samples derived from human.

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Mouse monoclonal [PCRP-TCF25-1A11] antibody to TCF25 for flow cytometry and WB with samples derived from human.

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Rabbit monoclonal [ARC1032] antibody to Olig2 for WB with samples derived from human, mouse and rat.

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Goat polyclonal antibody to CTDSP1 for ELISA, WB and IHC with samples derived from human and mouse.

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Rabbit polyclonal antibody to PHD2/prolyl hydroxylase for WB, IHC and ICC/IF with samples derived from Human, Mouse and Rat.

Supplier: ProSci Inc.

TNFRII (TNF Receptor II) is a member of the TNFR family of transmembrane proteins, and is expressed in immune cells and certain endothelial cells. It is a high affinity receptor for TNF alpha but manifests a lower affinity to TNF beta. Signaling through this receptor regulates various biological processes including cell proliferation, differentiation, apoptosis, lipid metabolism, coagulation, and neurotransmission. TNFRII consists of a 240 amino acid residue extracellular ligand binding portion, a 27 amino acid residue transmembrane segment and a 173 amino acid residue cytoplasmic domain.

Supplier: ProSci Inc.

NFKB1 or NFKB2 is bound to REL, RELA, or RELB to form the NFKB complex. The NFKB complex is inhibited by I-kappa-B proteins (NFKBIA or NFKBIB), which inactivate NF-kappa-B by trapping it in the cytoplasm. Phosphorylation of serine residues on the I-kappa-B proteins by kinases (IKBKA, or IKBKB) marks them for destruction via the ubiquitination pathway, thereby allowing activation of the NF-kappa-B complex. Activated NFKB complex translocates into the nucleus and binds DNA at kappa-B-binding motifs such as 5-prime GGGRNNYYCC 3-prime or 5-prime HGGARNYYCC 3-prime (where H is A, C, or T; R is an A or G purine; and Y is a C or T pyrimidine).

Supplier: ProSci Inc.

GITRL is expressed on dendritic cells (DC), monocytes, macrophages, B cells, activated T cells, endothelial cells, osteoclasts and various healthy non-lymphoid tissues (e. g. testis, . ). GITRL is constitutively expressed and released as soluble form by solid tumors and various hematopoietic malignancies. GITRL causes differentiation of osteoclasts, activation of macrophages, but also alteration of carcinoma and leukemia cells and influences apoptosis. Binding to GITR is important in regulating T-cell proliferation and TCR-mediated apoptosis. GITRL is implicated in development of autoimmune diseases and in the immune response against infectious pathogens and tumors.

Supplier: ProSci Inc.

Osteoprotegerin (OPG) is a member of the TNF receptor superfamily. This protein is an osteoblast-secreted decoy receptor that functions as a negative regulator of bone resorption. This protein specifically binds to its ligand, osteoprotegerin ligand (TNFSF11/OPGL), both of which are key extracellular regulators of osteoclast development. Studies of the mouse counterpart also suggest this protein and its ligand play a role in lymph-node organogenesis and vascular calcification. Alternatively spliced transcript variants of the gene have been reported, but their full length nature has not been determined.

Supplier: ProSci Inc.

EGR-1 belongs to the EGR family of C2H2-type zinc finger proteins. It is a nuclear protein and functions as a transcriptional regulator. EGR-1 recognises and binds to the DNA sequence 5'-CGCCCCCGC-3'(EGR-site).The products of target genes it activates are required for differentiation and mitogenesis. Studies suggest this is a tumour suppressor gene. EGR-1 has a distinct pattern of expression in the brain, and its induction has been shown to be associated with neuronal activity. Several studies suggest it has a role in neuronal plasticity. EGR-1 has also been found to regulate the expression of synaptobrevin II (a protein important for synaptic exocytosis).

Supplier: ProSci Inc.

SEC62 Antibody: SEC62 is an integral membrane protein located in the rough endoplasmic reticulum (ER) and is part of the SEC61-SEC62-SEC63 complex that is the central component of the protein translocation apparatus of the ER membrane. It is speculated that SEC61-SEC62-SEC63 may perform post-translational protein translocation into the ER and might also perform the backward transport of ER proteins that are subject to the ubiquitin-proteasome-dependent degradation pathway. Silencing of this gene with RNAi dramatically reduced the migration and invasive potential of numerous tumor cell lines, suggesting that it may be an attractive target for therapy of various tumors.