118481 Results for: "Butelki+i+butle&pageNo=30"

Supplier: Bioss

SNF5 is involved in transcriptional activation. The SWI/SNF complex is required for the induced expression of a large number of genes. This complex alters chromatin structure to facilitate binding of gene-specific dedicated transcription factors. SNF5 also funtions as a tumor suppressor gene and is frequently mutated in malignant rhabdoid tumors. It is also involved in adipocyte differentiation.

Supplier: Bioss

Plays a central role in autophagy. Required for the abcission step in cytokinesis. May play a role in antiviral host defense. Protects against infection by a neurovirulent strain of Sindbis virus.

Supplier: Bioss

The protein encoded by this gene is a regulatory protein involved in mitosis. The gene product complexes with p34(cdc2) to form the maturation-promoting factor (MPF). Two alternative transcripts have been found, a constitutively expressed transcript and a cell cycle-regulated transcript, that is expressed predominantly during G2/M phase. The different transcripts result from the use of alternate transcription initiation sites. [provided by RefSeq, Jul 2008].

Supplier: Bioss

E6-associating protein is a component of the ubiquitin-mediated proteolytic pathway, which selectively targets proteins for degradation by the 26S proteasome. Ubiquitin (Ub) is directly conjugated to protein substrates by the transfer of Ub from an E2 ubiquitin conjugating enzyme to the target protein. This conjugation is facilitated by the enzymatic activity of E3 ubiquitin ligase family members such as E6-AP. Several substrates of E6-AP have been identified and include the tumor suppressor protein p53 and the mammalian homolog of Rad23, HHR23A. Previous studies have indicated that E6-AP associates with the human papillomavirus E6 oncogene, which complexes with p53 and thereby potentiates E6-AP mediated ubiquitination of p53. Genetic mutations that impair E6-AP activity result in the accumulation of p53 in the cytoplasm, and, in many instances, these mutations are associated with the development of the rare neurodevelopmental disorder Angelman syndrome (AS), which is characterized by severe motor dysfunction and mental retardation.

Supplier: Bioss

Chromosome 1 is the largest human chromosome spanning about 260 million base pairs and making up 8% of the human genome. There are about 3,000 genes on chromosome 1, and considering the great number of genes there are also a large number of diseases associated with chromosome 1. Notably, the rare aging disease Hutchinson-Gilford progeria is associated with the LMNA gene which encodes lamin A. When defective, the LMNA gene product can build up in the nucleus and cause characteristic nuclear blebs. The mechanism of rapidly enhanced aging is unclear and is a topic of continuing exploration. The MUTYH gene is located on chromosome 1 and is partially responsible for familial adenomatous polyposis. Stickler syndrome, Parkinsons, Gaucher disease and Usher syndrome are also associated with chromosome 1. A breakpoint has been identified in 1q which disrupts the DISC1 gene and is linked to schizophrenia. Aberrations in chromosome 1 are found in a variety of cancers including head and neck cancer, malignant melanoma and multiple myeloma. The KIAA0562 gene product has been provisionally designated KIAA0562 pending further characterization.

Supplier: Bioss

Breast cancer metastasis-suppressor 1 (BRMS1) is 246 amino acid protein that acts as a mediator of metastasis suppression in several types of cancer including ovarian, lung, bladder, and murine mammary. BRMS1 mRNA is expressed in various tissues, including ovary, prostate, testis, and colon, but the protein is primarily detected in term placenta. BRMS1 suppresses metastasis without inhibiting tumorigenicity by modifying several metastasis-associated phenotypes. BRMS1 may participate in transcriptional regulation by binding to the mSin3/histone deacetylase complex. The expression of BRMS1 in certain cells increases connexin Cx43 expression and reduces connexin Cx32 expression. This produces a gap junction that increases intercellular communication, similar to those found in normal breast tissue. BRMS1 is stabilized by Hsp90 and may inhibit NF-â…¹B activity.

Supplier: Bioss

Protein kinases are enzymes that transfer a phosphate group from a phosphate donor onto an acceptor amino acid in a substrate protein. By this basic mechanism, protein kinases mediate most of the signal transduction in eukaryotic cells, regulating cellular metabolism, transcription, cell cycle progression, cytoskeletal rearrangement and cell movement, apoptosis, and differentiation. The protein kinase family is one of the largest families of proteins in eukaryotes, classified in 8 major groups based on sequence comparison of their tyrosine (PTK) or serine/threonine (STK) kinase catalytic domains. Epidermal Growth factor receptor (EGFR) is the prototype member of the type 1 receptor tyrosine kinases. EGFR overexpression in tumors indicates poor prognosis and is observed in tumors of the head and neck, brain, bladder, stomach, breast, lung, endometrium, cervix, vulva, ovary, esophagus, stomach and in squamous cell carcinoma.

Supplier: Apollo Scientific

(R)-3,3'-Bis(2,4,6-triisopropylphenyl)-[1,1'-binapthalene]-2,2'-diol

Supplier: Bioss

Identifies cytotoxic/suppressor T-cells that interact with MHC class I bearing targets. CD8 is thought to play a role in the process of T-cell mediated killing. CD8 alpha chains binds to class I MHC molecules alpha-3 domains.

Supplier: Bioss

Protein kinases are enzymes that transfer a phosphate group from a phosphate donor onto an acceptor amino acid in a substrate protein. By this basic mechanism, protein kinases mediate most of the signal transduction in eukaryotic cells, regulating cellular metabolism, transcription, cell cycle progression, cytoskeletal rearrangement and cell movement, apoptosis, and differentiation. The protein kinase family is one of the largest families of proteins in eukaryotes, classified in 8 major groups based on sequence comparison of their tyrosine (PTK) or serine/threonine (STK) kinase catalytic domains. Epidermal Growth factor receptor (EGFR) is the prototype member of the type 1 receptor tyrosine kinases. EGFR overexpression in tumors indicates poor prognosis and is observed in tumors of the head and neck, brain, bladder, stomach, breast, lung, endometrium, cervix, vulva, ovary, esophagus, stomach and in squamous cell carcinoma.

Supplier: Enzo Life Sciences

Produced in E. coli. Active Matrix Metalloproteinase-10 (MMP-10, stromelysin-2, transin-2) catalytic domain from human cDNA.

Supplier: Thermo Fisher Scientific

Manganese ≥99.6% (metals basis), powder APS <10 µm

Supplier: Thermo Fisher Scientific

Molecular sieve 3A (0.3 nm, 3 Å), powder <50 µm

Supplier: Thermo Fisher Scientific

Appearance: Dark brown Solution

Supplier: Greiner Bio-One

PP.

Supplier: Kautex

LDPE. Round. Natural colour.

Supplier: UVEX

Metal-free, flexible and lightweight safety ankle boots made from oiled hydro nubuck leather, upper resistant to liquid penetration plus a double-desity PU2D sole, highly slip resistant and resistant to oils and hydrocarbons.

Supplier: Apollo Scientific

(2,3-Dihydrothieno[3,4-b][1,4]dioxin-2-yl)methanol 95%

Supplier: Apollo Scientific

N1-[2-(2-Piperidyl)ethyl]-3,5-di(trifluoromethyl)aniline 97%

Supplier: Apollo Scientific

(Z)-N-{2-[3-chloro-5-(trifluoromethyl)pyridin-2-yl]-1-(3,4-dichlorophenyl)ethylidene}hydroxylamine

Supplier: Apollo Scientific

1-{2,6-Diazaspiro[3.3]heptan-2-yl}ethan-1-one hydrochloride

Supplier: Apollo Scientific

5-Methoxy-3,4-dihydro-1,8-naphthyridin-2(1H)-one 95%

Supplier: Apollo Scientific

4-Chloro-1,6-dimethyl-1H-pyrazolo[3,4-d]pyrimidine 95%

Supplier: Apollo Scientific

2,6-Di-O-methyl-β-cyclodextrine content > 35% (DS~14)

Supplier: Abcam

Rabbit monoclonal [EPR17839-130] to Fetuin A - BSA and Azide free (Detector).

Supplier: Abcam

Mouse monoclonal [AE20] to Cytokeratin 10 - BSA and Azide free.

Supplier: Abcam

Rabbit monoclonal [EPR24885-31] to PIRB - BSA and Azide free.

Supplier: Abcam

Rabbit monoclonal [EPR5067] to IL-32 - BSA and Azide free.

Supplier: Abcam

Rabbit monoclonal [EPR22451-306] to IFNAR2 - BSA and Azide free (Detector).

Supplier: Abcam

Rabbit monoclonal [EPR27481-32] to Arx - BSA and Azide free.