Supplier: Thermo Fisher Scientific

The Thermo Scientific™ IntelliStack™ CO₂ Incubator shaker is a versatile laboratory instrument used for incubating and agitating samples simultaneously. It combines the functions of an incubator and shaker, providing a controlled environment for cell culture, microbial growth, and various other applications. With adjustable temperature, speed, and CO₂ concentration settings, it offers precise control over experimental conditions. A large, easy-to-use 10" colour touchscreen display with alarms, alerts, real-time monitoring of key parameters, and data logging with export via USB or Ethernet allows for easy operation.

Supplier: LGC Standards PROMOCHEM

[EN]1,1-DIMETHYLETHYL [(4R,6S)-6-[(E)-2- 1 * 25 mg

Supplier: MP Biomedicals

Methotrexate is a cell cycle arresting agent with varying effects. Methotrexate has been reported to arrest the cell cycle in late G1/S thus leading to the inhibition of the synthesis of DNA, RNA, thymidylates, and proteins. The main mechanism of action is reported to involve the inhibition of enzymes involved in purine metabolism which leads to the accumulation of adenosine or the suppression of intercellular adhesion molecule expression by T cells. Additionally, this compound has been observed to inhibit DHFR.
Methotrexate is used for chemotherapy either alone or in combination with other agents. It is effective for the treatment of a number of cancers including: breast, head and neck, leukemia, lymphoma, lung, osteosarcoma, bladder, and trophoblastic neoplasms. It is also used in treatment of autoimmune diseases, ectopic pregnancy, and for the induction of medical abortions. It is used to inhibit dihydrofolate reductase in DHFR-based protein expression systems. Also effective in treatment of pyrimethamine-resistant Plasmodium vivax malaria parasites.
Potent inhibitor of dihydrofolate reductase and agent for antitumor studies. Use to inhibit dihydrofolate reductase in DHFR-based protein expression systems. Also shows immunosuppressive effects in, e.g., rheumatoid arthritis.
Methotrexate is an allosteric inhibititor of dihydrofolate reductase (DHFR), the enzyme that catalyzes the conversion of dihydrofolate to tetrahydrofolate. Since tetrahydrolfolate is required for purine and pyrimidine synthesis, methotrexate treatment results in the inhibition of DNA and RNA synthesis.

Supplier: MP Biomedicals

Storage: Store at Room Temperature (15-30 °C)
Glycine is a non-essential amino acid. It is only amino acid with no asymmetric carbon and thus is not chiral. It is the major inhibitory neurotransmitter. It is involved in the biosynthesis of the porphyrin rings of hemes and chlorophylls.
Glycine is commonly used in buffer solutions, in electrophoresis and preparative chromatography. A study of the folding of monoclonal antibodies in the presence of glycine and their subsequent purification has been published. The use of glycine in the purification of lipopolysaccharides, lipooligosaccharides, and lipid A has been reported. It is an amino acid for use in cell culture media development applications and existing media formulations. Glycine is commonly used as a component in Tris-glycine and Tris-glycine-SDS running buffers for polyacrylamide gel electrophoresis, a component of Towbin's transfer buffer for Western blots, a buffer substance in cryoenzymology, in osmotic pressure maintenance in isoelectric focusing of erythrocytes, salting-in effect in protein chemistry, and as a buffer component in the coupled phosphatase-kinase reaction for end labelling of restriction fragments. The growth requirements of various microorganisms is reported in the Handbook of Microbiology.
Glycine is a non-chiral amino acid that can be synthesized in the body from the amino acid serine by Serine Hydroxymethyltransferase. Inhibitory neurotransmitter in spinal cord, allosteric regulator of NMDA receptors.

Supplier: Thermo Fisher Scientific

The Thermo Scientific™ IntelliStack™ Incubator shaker is a versatile laboratory instrument used for incubating and agitating samples simultaneously. It combines the functions of an incubator and shaker, providing a controlled environment for cell culture, microbial growth, and various other applications. With adjustable temperature, speed, and humidity settings, it offers precise control over experimental conditions. A large, easy-to-use 10" colour touchscreen display with real-time monitoring of key parameters and alarms, alerts, and data logging with export via USB or Ethernet allows easy operation, enabling users to set and maintain specific temperature, speed, humidity level, and duration parameters to meet the requirements of various applications.

Supplier: Sartorius

WKŁAD FILTRACYJNY 300KD PESU SARTOCON 1 * 1 SET

Supplier: LABCONCO

Clean benches provide product protection from environmental contaminants for applications requiring a particulate-free work area, including plant tissue culture, electronic part inspection, syringe filling, medical device assembly, media plate preparation, and PCR.

Supplier: Honeywell Chemicals

HYDRANAL™-Composite is a frequently used pyridine-free Karl Fischer reagent. This one-component reagent has been proving its capabilities in volumetric titration for more than thirty five years in a large range of applications in the most diverse fields of research and industry.

The one component system have the following advantages:

Supplier: Biosensis

The capsaicin receptor (VR1, TRPV1) is a ligand-activated non-selective calcium permeant cation channel involved in detection of noxious chemical and thermal stimuli. The receptor seems to mediate proton influx and may be involved in intracellular acidosis in nociceptive neurons. It is involved in mediation of inflammatory pain and hyperalgesia. Sensitized by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases, which involves PKC isozymes and PCL. Activation by vanilloids, like capsaicin, and temperatures higher than 42 degrees Celsius, exhibits a time- and Ca2+-dependent outward rectification, followed by a long-lasting refractory state. Mild extracellular acidic pH (6.5) potentiates channel activation by noxious heat and vanilloids, whereas acidic conditions (pH less than 6) directly activate the channel. Can be activated by endogenous compounds, including 12-hydroperoxytetraenoic acid and bradykinin. Acts as ionotropic endocannabinoid receptor with central neuromodulatory effects. Triggers a form of long-term depression (TRPV1-LTD) mediated by the endocannabinoid anandamine in the hippocampus and nucleus accumbens by affecting AMPA receptors endocytosis (Ref: uniprot.org).

Supplier: Merck

SÓL SODOWA SULFOBURSZTYNIAN DIOKTYLU 96% 1 * 1 kg

Supplier: MOHR

[EN]TAPE HEATING MAX 400C, L. 5,0 M, 1 * 1 SZT

Supplier: Merck

(R)-(6,6'-DIMETHOXYBIPHENYL-2,2'-DIY 1 * 100 mg

Supplier: Merck

N,N-Methylenebisacrylamide for electrophoresis, >98%, powder 1 * 100 g

Supplier: CUSTOM MADE CHEMICALS LAB

8 COMPOUNDS 100 MG / L EACH IN METHANOL 1 * 100 mL

Supplier: BODO MULLER CHEMIE

BIFLAIR 66A 1 * 1 kg

Supplier: Merck

(S)-(6,6'-DIMETHOXYBIPHENYL-2,2'-DIY 1 * 100 mg

Supplier: MOHR

[EN]TAPE HEATING MAX 400C, L. 3,0 M, 1 * 1 SZT

Supplier: Merck

L-A-GLYCEROPHOSPHATE DI(MONO-*CYCLOHEXYL 1 * 1 g

Supplier: Merck

TITANIUM(IV) DIISOPROPOXIDEBIS(2,2,6 1 * 5 g

Supplier: Merck

(R)-(6,6'-DIMETHOXYBIPHENYL-2,2'-DIY 1 * 100 mg

Supplier: Merck

(R)-(6,6'-DIMETHOXYBIPHENYL-2,2'-DIY 1 * 500 mg

Supplier: BODO MULLER CHEMIE

BIFLAIR 66A 1 * 25 kg

Supplier: JUCHHEIM Laborgerate GmbH

[EN]GASKET FOR OIL RESERVOIR UP TO 2006 1 * 1 SZT

Supplier: JUCHHEIM Laborgerate GmbH

[EN]BOSSHEAD ROTATING, SPAN 20MM 1 * 1 SZT

Supplier: Merck

(R)-(6,6'-DIMETHOXYBIPHENYL-2,2'-DIY 1 * 5 g

Supplier: HUBER

[EN]PRESSURE-RESISTANT ENCAPSULATED TRAN 1 * 1 SZT

Supplier: HMC Europe GmbH

[EN]PRESSURE SENSOR 2,5BAR 1 * 1 SZT

Supplier: MOHR

[EN]TAPE HEATING MAX 450C, L. 2M, 500 W 1 * 1 SZT

Supplier: MOHR

[EN]TAPE HEATING MAX 400C, L. 2,0 M, 500 1 * 1 SZT

Supplier: BIOZYM

[EN]GREEN FREEZING CARTRIDGE FOR COOLBOX 1 * 3 SZT