49554 Results for: "Acetylenodikarboksylan+dimetylu&pageNo=8"

HIF1 (hypoxia-inducible factor 1), a heterodimeric transcription factor complex central to cellular response to hypoxia, consists of two subunits (alpha and beta) which are basic helix-loop-helix proteins of the PAS (Per, ARNT, Sim) family. Expression of HIF-1 alpha is regulated by cellular oxygen level alterations as well as in oxygen-independent manner via different cytokines (through the PI3K-AKT-mTOR pathway), growth factors, oncogenic activation, or loss of tumor suppressor function etc. In normoxic cells, HIF-1 alpha is proline hydroxylated leading to a conformational change that promotes its binding to the VLH (von Hippel Lindau) protein E3 ligase complex; ubiquitination and followed by rapid proteasomal degradation. Hypoxia as well as chemical hydroxylase inhibitors (desferrioxamine, cobalt etc.) inhibit HIF-1 alpha degradation and lead to its accumulation in the cells, whereas, contrastingly, HIF-1 beta/ARNT (AhR nuclear translocator) remains stable under both conditions. Besides their critical role in hypoxic response, HIFs regulates the transcription of genes responsible for angiogenesis, erythropoiesis/iron-metabolism, glucose metabolism, cell proliferation/survival, adipogenesis, carotid body formation, B lymphocyte development and immune reactions.

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EHNA ≥98% (by HPLC)

Supplier: Enzo Life Sciences

Phosphodiesterase PDE II inhibitor, IC50=0.8 µM. Also inhibits adenosine deaminase, Ki=4 nM.

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Rolipram ≥98% (by TLC)

Supplier: Enzo Life Sciences

PDE inhibitor

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6-Ketoprostaglandin-F1α ≥98% (by TLC)

Supplier: Enzo Life Sciences

Biosynthesis via hydrolysis of prostacyclin. A reliable parameter for measurement of prostacyclin. Ultra-pure.

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8-Methoxymethyl-IBMX ≥98% (by TLC)

Supplier: Enzo Life Sciences

Selective inhibitor of Ca2+-calmodulin-dependent phosphodiesterase (PDE I, IC50=4 µM).

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Guanosine 3',5'-cyclic Monophosphothioate, Rp-Isomer sodium salt ≥98% (by HPLC)

Supplier: Enzo Life Sciences

Inhibitor of cGMP-dependent protein kinase (PKG) 1α (cGMP antagonist). Resistant against mammalian cyclic nucleotid-dependent phosphodiesterases. No metabolic side effects. Low membrane permeability.

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5-Methylpyrazine-2-carboxylic acid-4-oxide 98+%

Supplier: Thermo Fisher Scientific

5-Methylpyrazine-2-carboxylic acid-4-oxide 98+%

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5-Methylcytidine 98%

Supplier: Thermo Fisher Scientific

5-Methylcytidine 98%

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(+)-Catechin monohydrate ≥98% (by HPLC)

Supplier: Enzo Life Sciences

Free radical scavenger.

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Ciprofloxacin hydrochloride monohydrate ≥98% (by HPLC)

Supplier: Enzo Life Sciences

Fluoroquinolone antibacterial agent. Inhibits bacterial DNA gyrase (topoisomerase). Inhibits cell division and causes double-strand breaks in the bacterial chromosome. Broad-spectrum antibiotic effective against Gram-positive, Gram-negative and anaerobic bacteria.

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MAHMA NONOate ≥98%

Supplier: Enzo Life Sciences

Nitric oxide (NO) donor.

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DETA NONOate (NOC-18) ≥97% (by 1H-NMR)

Supplier: Enzo Life Sciences

Nitric oxide (NO) donor.

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Guanosine-5'-O-(3-thiotriphosphate) tetralithium salt ≥85% (by HPLC)

Supplier: Enzo Life Sciences

Nonhydrolysable GTP analog.

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Decylubiquinone ≥98% (by TLC)

Supplier: Enzo Life Sciences

MPTP inhibitor

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Clopamide ≥98% (by HPLC)

Supplier: Enzo Life Sciences

Clinically useful diuretic. Clopamide selectively inhibits the chloride the sodium chloride cotransporter.

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L-Mimosine ≥98%

Supplier: Enzo Life Sciences

A rare plant amino acid that reversibly blocks the cell cycle at G1-phase. Inhibits the hydroxylation of deoxyhypusine and thus inhibits eukaryote initiation factor 5-A (eIF5-A). Inhibitor of mammalian tyrosinase and dopamine β-hydroxylase. Also chelates iron via the kojic acid metal-binding domain. Arrests DNA synthesis by inhibiting deoxyribonucleotide metabolism.