97201 Results for: "3-(4-Chlorophenyl)isoxazole&pageNo=9"

Supplier: ENZO LIFE SCIENCES

This is the active carboxylate form of mevastatin. It is active in whole cells as well as in cell free assays.

Supplier: ENZO LIFE SCIENCES

Methyltransferase inhibitor

Supplier: ENZO LIFE SCIENCES

Putative endogenous member of a growing family of lipo-amino acids (N-acyl amino acids).

Supplier: ENZO LIFE SCIENCES

A free radical scavenger and antioxidant. Displays beneficial effects in a rat model of ischemic brain damage.

Supplier: ENZO LIFE SCIENCES

Cannabinoid receptor ligand.

Supplier: ENZO LIFE SCIENCES

Antioxidant and chemopreventive

Supplier: ENZO LIFE SCIENCES

Inhibits the translocation of Akt.

Supplier: ENZO LIFE SCIENCES

URB-597 is a potent and selective inhibitor of the enzyme fatty acid amide hydrolase (FAAH), which is involved in the hydrolysis of endogenous cannabinoids such as anandamide. Inhibition of FAAH may serve to enhance the analgesic effects of endogenous cannabinoids. URB-597 has been shown to inhibit FAAH in rat cortical neuron membranes and in intact neurons with IC50 values of 4.6nM and 0.5nM, respectively. The compound has also been shown to have anxiolytic effects in rats (ID50=0.15mg/kg). Because URB-597 acts on FAAH and does not interfere with the binding of anandamide to the CB1 and CB2 receptors, it is a novel tool for drug development.

Supplier: ENZO LIFE SCIENCES

Tyrosine kinase inhibitor. It has been shown to block TNFα induced cytotoxicity and to block glucocorticoid-induced COX-2 activity in human amnion cells (IC50=21μM). It is also reported to inhibit guanylyl cyclase.

Supplier: ENZO LIFE SCIENCES

Endogenous [1] ligand for the CB1 receptor (CB1: Ki=52nm; CB2: Ki=1930nm [2]) and TRPV1 (Ki=5.78µM [3,4]). Inhibits NF-κB activation through direct binding to IKKβ [5] and induces apoptosis independently of cannabinoid or vanilloid receptors [6]. Activates the MAP kinase (MAPK/ERK) signalling pathway [7].

Supplier: ENZO LIFE SCIENCES

Pyruvate kinase M2 activator.

Supplier: ENZO LIFE SCIENCES

Endogenous cannabinoid. Weak ligand of CB1 (Ki=23.8µM) and CB2 (Ki=13.9µM) receptor. Inhibits fatty acid amide hydrolase (FAAH) (IC50=5.1µM). Immunosuppressant, anti-inflammatory, anti-nociceptive and anti-convulsant in vivo. The exact mode of action has not yet been revealed. It has been suggested that PEA: i) binds to a yet to be discovered cannabinoid receptor similar to CB2; ii) administered in vivo elicits the synthesis of endogenous agonists of CB2; iii) acts as an "entourage" compound by enhancing the activity and/or by influencing the turnover of endogenous agonists of CB2, possibly but not uniquely, by inhibiting their degradation.

Supplier: ENZO LIFE SCIENCES

Cannabinoid receptor ligand.

Supplier: ENZO LIFE SCIENCES

Arachidonic acid analog.

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Cannabinoid receptor ligand.

Supplier: Apollo Scientific

4,4'-Biphenol 99%

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PDE3 inhibitor

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Esterase inhibitor

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PARP-1 inhibitor

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Specific inhibitor of insulin-like growth factor-1 (IGF-1) and insulin receptor kinases. Induces apoptosis by downregulation of the expression of phospho-Akt1 and Bcl-2. Also increases Bax, p53 and p21 expression.

Supplier: ENZO LIFE SCIENCES

Irreversible inhibitor of serine proteases. Widely used fatty acid amid hydrolase (FAAH) inhibitor for pretreatment of brain membrane preparations when testing CB1 receptor activity. Spleen membranes used for CB2 studies do not require this pretreatment, as FAAH activity is absent in these cells. Inhibits also cysteine proteases like papain (reversible by DTT treatment, as well as internucleosomal DNA fragmentation in immature thymocytes. For a related, more stable inhibitor see AEBSF.

Supplier: ENZO LIFE SCIENCES

Inhibitor of CDK and GSK

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Slow-binding competitive inhibitor of arginase I (Ki=0.4-0.6µM & KD=2.22µM for recombinant rat liver arginase) and arginase II (Ki=0.31µM at pH 7.5 and 0.03µM at pH 9.5 for human recombinant type II arginase). Enhances NO-dependent smooth muscle relaxation in human penile corpus cavernosum tissue. Does not inhibit nitric oxide synthase (NOS) and may serve as a valuable reagent to probe the physiological relationship between arginase and NOS. Inhibitor of rat aortic smooth muscle cell proliferation.

Supplier: ENZO LIFE SCIENCES

Fatty acid synthase inhibitor

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Potent poly(ADP-ribose) polymerase-1 (PARP-1) inhibitor (IC50=450nM). Neuroprotectant.

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PKC inhibitor

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GTPase inhibitor

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D-erythro-Sphingosine-1-phosphate (caged) ≥95%

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Isoins(1,4,5)P3/PM (caged) ≥98% (by HPLC)

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The non-protein amino acid L-canavanine is an analog of L-arginine. Selective inducible nitric oxide synthase (iNOS; NOS II) inhibitor. Induces apoptotic cell death and shows antiproliferative and immunotoxic effects.