Protocadherins are a large family of cadherin-like cell adhesion proteins that are involved in the establishment and maintenance of neuronal connections in the brain. There are three protocadherin gene clusters, designated alpha, beta and gamma, all of which contain multiple tandemly arranged genes. PCDH10 (protocadherin 10), also known as PCDH19 or OL-PCDH, is a 1,040 amino acid single-pass type I membrane protein that contains six cadherin domains and one transmembrane domain. Expressed at moderate levels in brain, ovary and testis and present at lower levels in all other tissues, PCDH10 functions as a calcium-dependent cell-adhesion protein that may function as a tumor suppressor. When underexpressed, PCDH10 is associated with the progression of various carcinomas, including gastric cancer.

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Anti-factor 13 Rabbit Polyclonal Antibody (Cy5®)

Supplier: Bioss

Factor XIII is activated by thrombin and calcium ion to a transglutaminase that catalyses the formation of gamma-glutamyl-epsilon-lysine cross-links between fibrin chains, thus stabilizing the fibrin clot. Also cross-link alpha-2-plasmin inhibitor, or fibronectin, to the alpha chains of fibrin.

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Anti-factor 13 Rabbit Polyclonal Antibody (Cy3®)

Supplier: Bioss

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Anti-Claudin 17 Rabbit Polyclonal Antibody (Cy7®)

Supplier: Bioss

Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.

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Anti-Claudin 10 Rabbit Polyclonal Antibody (Cy3®)

Supplier: Bioss

The claudin superfamily consists of many structurally related proteins in humans. These proteins are important structural and functional components of tight junctions in paracellular transport. Claudins are located in both epithelial and endothelial cells in all tight junction-bearing tissues. Three classes of proteins are known to localize to tight junctions, including the claudins, Occludin and junction adhesion molecules. Claudins, which consist of four transmembrane domains and two extracellular loops, make up tight junction strands. Claudin expression is often highly restricted to specfic regions of different tissues and may have an important role in transcellular transport through tight junctions. Claudin-10 is a 228 amino acid multi-pass membrane protein that belongs to the claudin family and plays an important role in cell-adhesion activity and tight junction-specific events.

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3-(4-Chlorobenzylidene)-5-fluoro-1,3-dihydro-2H-indol-2-one

Supplier: Apollo Scientific

3-(4-Chlorobenzylidene)-5-fluoro-1,3-dihydro-2H-indol-2-one

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(8-Phenyl-1,4-dioxaspiro[4.5]dec-8-yl)methanamine

Supplier: Apollo Scientific

(8-Phenyl-1,4-dioxaspiro[4.5]dec-8-yl)methanamine

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Anti-14-3-3 Mouse Monoclonal Antibody [clone: 3G12]

Supplier: Biosensis

14.3.3 protein eta or 14.3.3 binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner (Ref SwissProt). 14.3.3 protein eta is widely expressed as both homodimers and heterodimers and are concentrated in the nervous system. High concentrations of 14.3.3 protein eta have been linked to Creutzfeld Jacob Disease, Parkinson's Disease and early-onset schizopherenia.