Mouse recombinant PDL2

50 µG

Catalog # PRSI92-497

Supplier: ProSci Inc.

Catalog # PRSI92-497

Supplier: ProSci Inc.

CAS Number:

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Specifications

CAS Number:

Price

1 510 zł

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Product Details & Documents

Programmed cell death 1 ligand 2 (PD-L2), also known as butyrophilin B7-DC or PDCD1 ligand 2, belongs to the member of B7 family which can regulate the activation and tolerance of T cells. PD-L2 is one ligand for Programmed cell death 1(PD-1), and the other is PD-L1. These two ligands shares 34% aa sequence identity. Mouse PD-L2 gene encodes a 273 amino acids (aa) protein with a putative 19 aa signal peptide, a 201 aa extracellular region , a 21 aa transmembrane domain and a 32 aa cytoplasmic region. The mouse PD-L2 gene is highly expressed in heart, placenta, pancreas, lung and liver while expressed weakly in spleen, lymph nodes and thymus. Besides, the expression of PD-L2 gene can be induced on dendritic cells grown from peripheral blood mononuclear cells under CSF2 and IL4/interleukin-4 treatment, and up-regulated by IFNG/IFN-gamma stimulation in monocytes. PD-L2 usually functions in a PDCD1-independent manner and is involved in regulating costimulatory signal which is essential for T-cell proliferation and IFNG production. Recent studies demonstrate that the expression of PD-L2 on the tumour cells promotes CD8 T cell–mediated rejection of tumour cells, at both the induction and effector phase of antitumour immunity. Moreover, PD-L2 binds to PD-1 cells and enhances T cell killing in a PD-1–independent mechanism.

This recombinant protein can be used for biological assays. For research use only.

Fusion-Tag: C-Fc tag

This recombinant protein can be used for biological assays. For research use only.

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Specifications

Pk:
50 µG
Cat. No.:
PRSI92-497
Protein/peptide type:
Recombinant
Protein/peptide name:
PDL2
Storage conditions:
Lyophilized protein should be stored at −20 °C, though stable at room temperature for 3 weeks. Reconstituted protein solution can be stored at 4-7 °C for 2-7 days. Aliquots of reconstituted samples are stable at −20 °C for 3 months.
Formulation:
Lyophilized from a 0.2 um filtered solution of 20mM PB, 150mM NaCl, pH 7.4. Always centrifuge tubes before opening. Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100 ug/ml. Dissolve the Lyophilized protein in ddH2O. Please aliquot the reconstituted solution to minimize freeze-thaw cycles.
Protein synonyms:
CD273|PD-L2|Pdcd1lg2|Programmed Cell Death 1 ligand 2|PD-1 ligand 2|B7-DC|PDCD1 ligand 2
Purity:
> 95% as determined by reducing SDS-PAGE
Tag sequence:
C-Fc tag
Sequence:
Leu20-Arg219
Species:
Mouse
Molecular weight:
49.7 kD